PAIR_ID	Molecule_pattern_type	Molecule_pattern	Molecule_method	Cell pathway Regulation
PAIR0038529	Lactylation	K247	Western blot analysis	.
PAIR0038530	Lactylation	K76	Liquid chromatography mass spectrometry (LC-MS)	.
PAIR0038531	Lactylation	K76	Liquid chromatography mass spectrometry (LC-MS)	.
PAIR0038532	Lactylation	K70	Mass spectrometry analysis	.
PAIR0038533	Lactylation	K70	Mass spectrometry analysis	.
PAIR0038534	Lactylation	.	.	.
PAIR0038535	Lactylation	.	.	.
PAIR0038536	Lactylation	.	.	.
PAIR0038537	Lactylation	.	.	.
PAIR0038538	Lactylation	.	.	.
PAIR0038539	Lactylation	.	.	.
PAIR0038540	Expression	Up-regulation	Immunohistochemical (IHC) staining	.
PAIR0038541	Expression	Up-regulation	Immunohistochemical (IHC) staining	.
PAIR0038542	Expression	Down-regulation	Immunohistochemical (IHC) staining	.
PAIR0038543	Expression	Down-regulation	Immunohistochemical (IHC) staining	.
PAIR0038544	Expression	Up-regulation	RT-qPCR	.
PAIR0038545	Expression	Up-regulation	RT-qPCR	.
PAIR0038546	Expression	Up-regulation	qRT-PCR	.
PAIR0038547	Expression	Up-regulation	Western blot analysis	.
PAIR0038548	Expression	Up-regulation	Western blot analysis	.
PAIR0038549	Expression	Up-regulation	qPCR	.
PAIR0038550	Expression	Up-regulation	qPCR	.
PAIR0038551	Expression	Up-regulation	DNA-binding assays	.
PAIR0038552	Expression	Up-regulation	Real-time PCR	WNT/beta-catenin pathway
PAIR0038553	Expression	Up-regulation	Real-time PCR	WNT/beta-catenin pathway
PAIR0038554	Expression	Up-regulation	Real-time PCR	WNT/beta-catenin pathway
PAIR0038555	Expression	Up-regulation	Real-time PCR	WNT/beta-catenin pathway
PAIR0038556	Expression	Up-regulation	Whole-transcriptome expression array	.
PAIR0038557	Expression	Up-regulation	Whole-transcriptome expression array	.
PAIR0038558	Expression	Up-regulation	qRT-PCR	.
PAIR0038559	Expression	Up-regulation	Western blot analysis	.
PAIR0038560	Expression	Up-regulation	Western blot analysis	.
PAIR0038561	Expression	Up-regulation	Western blot analysis	.
PAIR0038562	Expression	Up-regulation	Western blot analysis	.
PAIR0038563	Expression	Up-regulation	Western blot analysis	.
PAIR0038564	Expression	Down-regulation	Western blot analysis	.
PAIR0038565	SUMOylated	K315	Western blot analysis	.
PAIR0038566	Expression	Up-regulation	Western blot analysis	.
PAIR0038567	Expression	Up-regulation	Western blot analysis	.
PAIR0038568	Expression	Up-regulation	Western blot analysis	.
PAIR0038569	Expression	Up-regulation	Western blot analysis	.
PAIR0038570	Expression	Up-regulation	Western blot analysis	.
PAIR0038571	Expression	Up-regulation	qRT-PCR and Western blot	HKDC1/G3BP7/PRKDC pathway
PAIR0038572	Expression	Up-regulation	qRT-PCR and Western blot	HKDC1/G3BP8/PRKDC pathway
PAIR0038573	Expression	Up-regulation	.	.
PAIR0038574	Expression	Up-regulation	Western blot analysis	.
PAIR0038575	Expression	Up-regulation	Western blot analysis	.
PAIR0038576	Expression	Down-regulation	Western blot analysis	.
PAIR0038577	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038578	Expression	Up-regulation	qRT-PCR; Western blot analysis	TGF-beta signaling pathway (+|hsa04350)
PAIR0038579	Expression	Up-regulation	qRT-PCR; Western blot analysis	TGF-beta signaling pathway (+|hsa04350)
PAIR0038580	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038581	Expression	Down-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038582	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038583	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038584	Expression	Down-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038585	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038586	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038587	Expression	Down-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038588	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038589	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038590	Expression	Down-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038591	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038592	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038593	Expression	Up-regulation	qRT-PCR	.
PAIR0038594	Expression	Up-regulation	Western blot analysis	.
PAIR0038595	Expression	Up-regulation	Western blot analysis	.
PAIR0038596	Expression	Up-regulation	Western blot analysis	.
PAIR0038597	Expression	Up-regulation	Western blot analysis	JAK-STAT signaling pathway (+|hsa04630); Insulin resistance (+|hsa04931)
PAIR0038598	Expression	Up-regulation	Western blot analysis	JAK-STAT signaling pathway (+|hsa04630); Insulin resistance (+|hsa04931)
PAIR0038599	Expression	Up-regulation	MRNA level and western blot analysis	.
PAIR0038600	Expression	Up-regulation	RNA sequencing	.
PAIR0038601	Expression	Up-regulation	Transcriptome sequencing and analysis	.
PAIR0038602	Expression	Up-regulation	Transcriptome sequencing and analysis	.
PAIR0038603	Expression	Up-regulation	qPCR	.
PAIR0038604	Expression	Up-regulation	 Western blotting and quantitative reverse transcription polymerase chain reaction	Hepatocellular carcinoma (+|hsa05225); Fluid shear stress and atherosclerosis (+|hsa05418)
PAIR0038605	Expression	Up-regulation	Real time PCR	HIF-1 signaling pathway (+|hsa04066)
PAIR0038606	Lactylation	K388	LC-MS/MS analysis	.
PAIR0038607	Expression	Up-regulation	RT-qPCR	.
PAIR0038608	Expression	Up-regulation	Expression profiles	.
PAIR0038609	Expression	Up-regulation	"Western blot analysis, qRT-PCR and CO-IP"	.
PAIR0038610	Expression	Up-regulation	Western blot analysis	.
PAIR0038611	Expression	Up-regulation	Western blot analysis	.
PAIR0038612	Expression	Up-regulation	qRT-PCR	.
PAIR0038613	Expression	Up-regulation	.	.
PAIR0038614	Expression	Up-regulation	 Western blotting and quantitative reverse transcription polymerase chain reaction	Hepatocellular carcinoma (+|hsa05225); Fluid shear stress and atherosclerosis (+|hsa05418)
PAIR0038615	Expression	Up-regulation	 Western blotting and quantitative reverse transcription polymerase chain reaction	Hepatocellular carcinoma (+|hsa05225); Fluid shear stress and atherosclerosis (+|hsa05418)
PAIR0038616	Expression	Up-regulation	 Western blotting and quantitative reverse transcription polymerase chain reaction	Hepatocellular carcinoma (+|hsa05225); Fluid shear stress and atherosclerosis (+|hsa05418)
PAIR0038617	Expression	Up-regulation	 Western blotting and quantitative reverse transcription polymerase chain reaction	Hepatocellular carcinoma (+|hsa05225); Fluid shear stress and atherosclerosis (+|hsa05418)
PAIR0038618	Mutation	.	qRT-PCR	.
PAIR0038619	Expression	Up-regulation	qRT-PCR	.
PAIR0038620	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038621	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038622	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038623	Mutation	.	.	.
PAIR0038624	Expression	Up-regulation	.	.
PAIR0038625	Expression	Up-regulation	 Western blotting and quantitative reverse transcription polymerase chain reaction	Hepatocellular carcinoma (+|hsa05225); Fluid shear stress and atherosclerosis (+|hsa05418)
PAIR0038626	Expression	Up-regulation	.	.
PAIR0038627	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038628	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038629	Expression	Up-regulation	RNA sequencing	.
PAIR0038630	Expression	Up-regulation	Western blot analysis	.
PAIR0038631	Expression	Up-regulation	Western blot analysis	.
PAIR0038632	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038633	Expression	Up-regulation	Western blot analysis	.
PAIR0038634	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038635	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038636	Expression	Up-regulation	Western blot analysis	.
PAIR0038637	Phosphorylation	S1016	.	.
PAIR0038638	Expression	Up-regulation	Transcriptome sequencing and analysis	.
PAIR0038639	Methylation	.	.	.
PAIR0038640	Expression	Up-regulation	Transcriptome sequencing and analysis	.
PAIR0038641	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038642	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038643	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038644	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038645	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038646	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038647	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038648	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038649	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038650	Expression	Up-regulation	qRT-PCR; Western blot analysis	HIF-1 signaling pathway (+|hsa04066)
PAIR0038651	Expression	Up-regulation	RPPA	.
PAIR0038652	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038653	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038654	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038655	Expression	Up-regulation	Expression profiles	.
PAIR0038656	Expression	Up-regulation	Expression profiles	.
PAIR0038657	Expression	Down-regulation	qRT-PCR	.
PAIR0038658	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038659	Expression	Up-regulation	qRT-PCR; Western blot analysis	Longevity regulating pathway - multiple species (+|hsa04213); Breast cancer (+|hsa05224); Wnt signaling pathway (+|hsa04310); Adherens junction (+|hsa04520)
PAIR0038660	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038661	Expression	Up-regulation	MRNA level and western blot analysis	.
PAIR0038662	Expression	Up-regulation	qRT-PCR	.
PAIR0038663	Expression	Up-regulation	MRNA level and western blot analysis	.
PAIR0038664	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038665	Expression	Up-regulation	Western blot analysis	.
PAIR0038666	Expression	Up-regulation	Western blot analysis	.
PAIR0038667	Expression	Up-regulation	Western blot analysis	.
PAIR0038668	Expression	Up-regulation	Western blot analysis	.
PAIR0038669	Expression	Up-regulation	Western blot analysis	.
PAIR0038670	Expression	Up-regulation	Western blot analysis	.
PAIR0038671	Expression	Up-regulation	Western blot analysis	.
PAIR0038672	Expression	Up-regulation	Western blot analysis	.
PAIR0038673	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038674	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038675	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038676	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038677	Expression	Down-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038678	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038679	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038680	Expression	Up-regulation	Expression profiles	.
PAIR0038681	Expression	Up-regulation	Expression profiles	.
PAIR0038682	Expression	Up-regulation	Real-time PCR	.
PAIR0038683	Expression	Up-regulation	Western blot analysis and immunohistochemical assays	Cholesterol metabolism (+|hsa04979)
PAIR0038684	Expression	Up-regulation	Western blot analysis and immunohistochemical assays	Cholesterol metabolism (+|hsa04979)
PAIR0038685	Expression	Up-regulation	Real-time PCR	.
PAIR0038686	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038687	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038688	Expression	Down-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038689	Expression	Up-regulation	Western blot analysis	.
PAIR0038690	Expression	Up-regulation	Western blot analysis	.
PAIR0038691	Expression	Up-regulation	Western blot analysis	.
PAIR0038692	Expression	Up-regulation	Western blot analysis	.
PAIR0038693	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038694	Methylation	H3K36me2	qRT-PCR	.
PAIR0038695	Expression	Up-regulation	qRT-PCR	.
PAIR0038696	Expression	Up-regulation	qRT-PCR	.
PAIR0038697	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038698	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038699	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038700	Expression	Up-regulation	Western blot analysis	.
PAIR0038701	Expression	Up-regulation	Western blot analysis	.
PAIR0038702	Mutation	.	LC-MS	.
PAIR0038703	Expression	Down-regulation	qRT-PCR	.
PAIR0038704	Expression	Up-regulation	Western blot analysis	.
PAIR0038705	Expression	Up-regulation	Western blot analysis	.
PAIR0038706	Expression	Up-regulation	Western blot analysis	MAPK signaling pathway (+|hsa04010); PI3K-Akt signaling pathway (+|hsa04151)
PAIR0038707	Expression	Up-regulation	.	.
PAIR0038708	Expression	Up-regulation	Western blot analysis	.
PAIR0038709	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038710	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038711	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038712	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038713	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038714	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038715	Expression	Up-regulation	qRT-PCR	.
PAIR0038716	Expression	Up-regulation	qRT-PCR	.
PAIR0038717	Expression	Up-regulation	qRT-PCR; Western blot analysis	Metabolic pathways (+|hsa01100); Transcriptional misregulation in cancer (+|hsa05202)
PAIR0038718	Expression	Up-regulation	qRT-PCR	.
PAIR0038719	Expression	Up-regulation	qRT-PCR	.
PAIR0038720	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038721	Phosphorylation	tyrosine-289	.	.
PAIR0038722	Expression	Up-regulation	qRT-PCR; Western blot analysis	IL-17 signaling pathway (+|hsa04657)
PAIR0038723	Expression	Up-regulation	qRT-PCR; Western blot analysis	TGF-beta signaling pathway (+|hsa04350)
PAIR0038724	Expression	Up-regulation	qRT-PCR; Western blot analysis	TGF-beta signaling pathway (+|hsa04350)
PAIR0038725	Expression	Up-regulation	qRT-PCR; Western blot analysis	TGF-beta signaling pathway (+|hsa04350)
PAIR0038726	Expression	Up-regulation	qRT-PCR; Western blot analysis	TGF-beta signaling pathway (+|hsa04350)
PAIR0038727	Expression	Up-regulation	qRT-PCR; Western blot analysis	TGF-beta signaling pathway (+|hsa04350)
PAIR0038728	Expression	Up-regulation	Western blot analysis	Cushing syndrome (+|hsa04934) 
PAIR0038729	Expression	Up-regulation	Western blot analysis	Cushing syndrome (+|hsa04934) 
PAIR0038730	Mutation	.	.	Longevity regulating pathway - multiple species (+|hsa04213)
PAIR0038731	Mutation	.	.	Longevity regulating pathway - multiple species (+|hsa04213)
PAIR0038732	Expression	Up-regulation	qRT-PCR	.
PAIR0038733	Expression	Up-regulation	qRT-PCR	.
PAIR0038734	Expression	Up-regulation	RNA seq; Western blot analysis	.
PAIR0038735	Expression	Up-regulation	RNA seq; Western blot analysis	.
PAIR0038736	.	.	.	MAPK signaling pathway (+|hsa04010); Insulin signaling pathway (+|hsa04910); mTOR signaling pathway (+|hsa04150)
PAIR0038737	.	.	.	MAPK signaling pathway (+|hsa04010); Insulin signaling pathway (+|hsa04910); mTOR signaling pathway (+|hsa04150)
PAIR0038738	Expression	Up-regulation	RNA seq	.
PAIR0038739	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038740	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038741	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038742	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038743	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038744	Expression	Down-regulation	Western blot analysis	.
PAIR0038745	Expression	Down-regulation	Western blot analysis	.
PAIR0038746	Expression	Up-regulation	Western blot analysis	.
PAIR0038747	Mutation	.	.	Hippo signaling pathway (+|hsa04390)
PAIR0038748	Mutation	.	.	Hippo signaling pathway (+|hsa04390)
PAIR0038749	Mutation	.	CE-TOF/MS	.
PAIR0038750	Mutation	.	CE-TOF/MS	.
PAIR0038751	Mutation	.	CE-TOF/MS	.
PAIR0038752	Mutation	.	CE-TOF/MS	.
PAIR0038753	Mutation	.	CE-TOF/MS	.
PAIR0038754	Expression	Up-regulation	qRT-PCR	.
PAIR0038755	Expression	Up-regulation	qRT-PCR	.
PAIR0038756	Expression	Up-regulation	qRT-PCR	.
PAIR0038757	Expression	Up-regulation	qRT-PCR	.
PAIR0038758	.	.	.	MAPK signaling pathway (+|hsa04010); Insulin signaling pathway (+|hsa04910); mTOR signaling pathway (+|hsa04150)
PAIR0038759	.	.	.	MAPK signaling pathway (+|hsa04010); Insulin signaling pathway (+|hsa04910); mTOR signaling pathway (+|hsa04150)
PAIR0038760	Expression	Up-regulation	qRT-PCR	.
PAIR0038761	Expression	Down-regulation	qRT-PCR; Western blot analysis	.
PAIR0038762	Expression	Down-regulation	qRT-PCR; Western blot analysis	.
PAIR0038763	Lactylation	K388	LC-MS/MS analysis	.
PAIR0038764	Expression	Up-regulation	Western blot analysis	.
PAIR0038765	Activity	activation	Western blot analysis	.
PAIR0038766	Expression	Up-regulation	Western blot analysis	.
PAIR0038767	Expression	Up-regulation	Western blot analysis	.
PAIR0038768	Expression	Up-regulation	Western blot analysis	.
PAIR0038769	Expression	Up-regulation	Western blot analysis	.
PAIR0038770	Expression	Up-regulation	qRT-PCR; Western blot analysis	Biosynthesis of terpenoids and steroids (+|hsa01062); Indole diterpene alkaloid biosynthesis (+|hsa00403)
PAIR0038771	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038772	Lactylation	H3K9la	Western blot analysis	.
PAIR0038773	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038774	Expression	Up-regulation	Western blot analysis	.
PAIR0038775	Expression	Up-regulation	qRT-PCR	.
PAIR0038776	Expression	Up-regulation	qRT-PCR	.
PAIR0038777	Expression	Up-regulation	qRT-PCR	.
PAIR0038778	Expression	Up-regulation	qRT-PCR	.
PAIR0038779	Lactylation	K247	Western blot analysis	.
PAIR0038780	Lactylation	K247	Western blot analysis	.
PAIR0038781	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038782	Expression	Up-regulation	qPCR	.
PAIR0038783	Expression	Up-regulation	qRT-PCR	.
PAIR0038784	Expression	Up-regulation	qRT-PCR	.
PAIR0038785	Expression	Up-regulation	qPCR	.
PAIR0038786	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038787	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038788	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038789	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038790	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038791	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038792	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038793	Expression	Up-regulation	Western blot analysis	mTOR signaling pathway (+|hsa04150); Insulin signaling pathway (+|hsa04910)
PAIR0038794	Expression	Up-regulation	Western blot analysis	mTOR signaling pathway (+|hsa04150); Insulin signaling pathway (+|hsa04910)
PAIR0038795	Expression	Up-regulation	qRT-PCR	.
PAIR0038796	Expression	Up-regulation	Western blot analysis	.
PAIR0038797	Mutation	.	LC-MS	.
PAIR0038798	Phosphorylation	tyrosine-289	.	.
PAIR0038799	Phosphorylation	tyrosine-289	.	.
PAIR0038800	Phosphorylation	tyrosine-289	.	.
PAIR0038801	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038802	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038803	Expression	Up-regulation	RNA seq; Western blot analysis	.
PAIR0038804	Expression	Up-regulation	RNA seq; Western blot analysis	.
PAIR0038805	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038806	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038807	Expression	Up-regulation	.	.
PAIR0038808	.	.	.	PI3K-Akt signaling pathway (+|hsa04151)
PAIR0038809	Expression	Up-regulation	Western blot analysis	.
PAIR0038810	.	.	.	PI3K-Akt signaling pathway (+|hsa04151)
PAIR0038811	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038812	SUMOylated	K315	Western blot analysis	.
PAIR0038813	SUMOylated	K315	Western blot analysis	.
PAIR0038814	SUMOylated	K315	Western blot analysis	.
PAIR0038815	SUMOylated	K315	Western blot analysis	.
PAIR0038816	SUMOylated	K492	Western blot analysis	.
PAIR0038817	SUMOylated	K492	Western blot analysis	.
PAIR0038818	SUMOylated	K492	Western blot analysis	.
PAIR0038819	SUMOylated	K492	Western blot analysis	.
PAIR0038820	Expression	Up-regulation	Expression profiles	.
PAIR0038821	SUMOylated	K315	Western blot analysis	.
PAIR0038822	SUMOylated	K315	Western blot analysis	.
PAIR0038823	SUMOylated	K492	Western blot analysis	.
PAIR0038824	SUMOylated	K492	Western blot analysis	.
PAIR0038825	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038826	Expression	Up-regulation	Western blot analysis	.
PAIR0038827	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038828	Expression	Up-regulation	Western blot analysis	.
PAIR0038829	Expression	Up-regulation	Western blot analysis	.
PAIR0038830	Expression	Up-regulation	Western blot analysis	.
PAIR0038831	Expression	Up-regulation	Western blot analysis	.
PAIR0038832	Expression	Up-regulation	Western blot analysis	.
PAIR0038833	Expression	Up-regulation	Western blot analysis	.
PAIR0038834	Expression	Up-regulation	qRT-PCR	.
PAIR0038835	Expression	Up-regulation	qRT-PCR	.
PAIR0038836	Expression	Up-regulation	qRT-PCR	.
PAIR0038837	Expression	Up-regulation	qRT-PCR	.
PAIR0038838	.	.	.	MAPK signaling pathway (+|hsa04010); Insulin signaling pathway (+|hsa04910); mTOR signaling pathway (+|hsa04150)
PAIR0038839	.	.	.	MAPK signaling pathway (+|hsa04010); Insulin signaling pathway (+|hsa04910); mTOR signaling pathway (+|hsa04150)
PAIR0038840	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038841	Expression	Up-regulation	Western blot analysis	.
PAIR0038842	Expression	Up-regulation	Western blot analysis	.
PAIR0038843	Expression	Up-regulation	qRT-PCR	.
PAIR0038844	Expression	Up-regulation	qRT-PCR	.
PAIR0038845	Expression	Up-regulation	qRT-PCR	.
PAIR0038846	Expression	Up-regulation	qRT-PCR	.
PAIR0038847	Expression	Up-regulation	qRT-PCR	.
PAIR0038848	Expression	Up-regulation	qRT-PCR	.
PAIR0038849	Expression	Up-regulation	qRT-PCR	.
PAIR0038850	Expression	Up-regulation	qRT-PCR	.
PAIR0038851	Expression	Up-regulation	qRT-PCR	.
PAIR0038852	Expression	Up-regulation	qRT-PCR	.
PAIR0038853	Expression	Up-regulation	qRT-PCR	.
PAIR0038854	Expression	Up-regulation	qRT-PCR	.
PAIR0038855	Expression	Up-regulation	qRT-PCR	.
PAIR0038856	Expression	Up-regulation	qRT-PCR	.
PAIR0038857	Expression	Up-regulation	qRT-PCR	.
PAIR0038858	Expression	Up-regulation	qRT-PCR	.
PAIR0038859	Expression	Up-regulation	qRT-PCR	.
PAIR0038860	Expression	Up-regulation	qRT-PCR	.
PAIR0038861	Expression	Up-regulation	Transcriptome datasets	.
PAIR0038862	Expression	Up-regulation	Transcriptome datasets	.
PAIR0038863	Expression	Down-regulation	qRT-PCR; Western blot analysis	.
PAIR0038864	Expression	Up-regulation	Transcriptome datasets	.
PAIR0038865	Expression	Up-regulation	Transcriptome datasets	.
PAIR0038866	Expression	Up-regulation	qRT-PCR; Western blot analysis	HIF-1 signaling pathway (+|hsa04066); VEGF signaling pathway (+|hsa04370)
PAIR0038867	Expression	Up-regulation	qRT-PCR; Western blot analysis	HIF-1 signaling pathway (+|hsa04066); VEGF signaling pathway (+|hsa04370)
PAIR0038868	Expression	Up-regulation	qRT-PCR; Western blot analysis	HIF-1 signaling pathway (+|hsa04066); VEGF signaling pathway (+|hsa04370)
PAIR0038869	Expression	Up-regulation	qRT-PCR; Western blot analysis	HIF-1 signaling pathway (+|hsa04066); VEGF signaling pathway (+|hsa04370)
PAIR0038870	Expression	Up-regulation	qRT-PCR; Western blot analysis	HIF-1 signaling pathway (+|hsa04066); VEGF signaling pathway (+|hsa04370)
PAIR0038871	Expression	Up-regulation	qRT-PCR; Western blot analysis	HIF-1 signaling pathway (+|hsa04066); VEGF signaling pathway (+|hsa04370)
PAIR0038872	Expression	Up-regulation	qRT-PCR; Western blot analysis	Central carbon metabolism in cancer (+|hsa05230)
PAIR0038873	Expression	Down-regulation	qRT-PCR; Western blot analysis	Central carbon metabolism in cancer (+|hsa05230)
PAIR0038874	Expression	Up-regulation	qRT-PCR; Western blot analysis	Central carbon metabolism in cancer (+|hsa05230)
PAIR0038875	Expression	Up-regulation	qRT-PCR; Western blot analysis	Central carbon metabolism in cancer (+|hsa05230)
PAIR0038876	Expression	Down-regulation	qRT-PCR; Western blot analysis	Central carbon metabolism in cancer (+|hsa05230)
PAIR0038877	Expression	Up-regulation	qRT-PCR; Western blot analysis	Central carbon metabolism in cancer (+|hsa05230)
PAIR0038878	Expression	Down-regulation	.	.
PAIR0038879	Expression	Down-regulation	.	.
PAIR0038880	Expression	Down-regulation	.	.
PAIR0038881	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038882	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038883	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038884	Expression	Up-regulation	Western blot analysis	.
PAIR0038885	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038886	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038887	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038888	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038889	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038890	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038891	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038892	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038893	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038894	Expression	Up-regulation	qRT-PCR	.
PAIR0038895	Expression	Up-regulation	qRT-PCR	.
PAIR0038896	Expression	Up-regulation	qRT-PCR	.
PAIR0038897	Expression	Up-regulation	qRT-PCR	.
PAIR0038898	Expression	Up-regulation	qRT-PCR	.
PAIR0038899	Expression	Up-regulation	qRT-PCR	.
PAIR0038900	Expression	Up-regulation	Western blot analysis	.
PAIR0038901	Expression	Up-regulation	Western blot analysis	.
PAIR0038902	Expression	Up-regulation	Western blot analysis	.
PAIR0038903	Expression	Up-regulation	Western blot analysis	.
PAIR0038904	Expression	Up-regulation	Western blot analysis	.
PAIR0038905	Expression	Up-regulation	Western blot analysis	.
PAIR0038906	Expression	Up-regulation	Western blot analysis	.
PAIR0038907	Expression	Up-regulation	Proteomics	.
PAIR0038908	Expression	Up-regulation	Western blot analysis	.
PAIR0038909	Expression	Up-regulation	Western blot analysis	.
PAIR0038910	Expression	Up-regulation	Western blot analysis	.
PAIR0038911	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038912	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038913	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038914	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038915	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038916	Expression	Up-regulation	.	mTOR signaling pathway (+|hsa04150); AMPK signaling pathway (+|hsa04152); Insulin signaling pathway (+|hsa04910)
PAIR0038917	Expression	Up-regulation	.	mTOR signaling pathway (+|hsa04150); AMPK signaling pathway (+|hsa04152); Insulin signaling pathway (+|hsa04910)
PAIR0038918	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038919	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038920	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038921	Expression	Up-regulation	Western blot analysis	.
PAIR0038922	Expression	Up-regulation	qRT-PCR	.
PAIR0038923	Expression	Down-regulation	qRT-PCR	.
PAIR0038924	Lactylation	K388	LC-MS/MS analysis	.
PAIR0038925	Expression	Up-regulation	qRT-PCR and Western blot	Non-homologous end-joining (+|hsa03450)
PAIR0038926	Expression	Up-regulation	qRT-PCR and Western blot	.
PAIR0038927	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038928	Expression	Up-regulation	qRT-PCR and Western blot	.
PAIR0038929	Expression	Up-regulation	qRT-PCR and Western blot	.
PAIR0038930	Expression	Down-regulation	qRT-PCR and Western blot	.
PAIR0038931	Expression	Down-regulation	qRT-PCR and Western blot	.
PAIR0038932	Expression	Down-regulation	qRT-PCR	.
PAIR0038933	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038934	Lactylation	K388	LC-MS/MS analysis	.
PAIR0038935	Expression	Up-regulation	Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0038936	Expression	Up-regulation	RNA seq	.
PAIR0038937	Expression	Up-regulation	RNA seq	.
PAIR0038938	Expression	Up-regulation	qRT-PCR	.
PAIR0038939	Expression	Up-regulation	Western blot analysis	FoxO signaling pathway (+|hsa04068)
PAIR0038940	Expression	Down-regulation	Western blot analysis	FoxO signaling pathway (+|hsa04068)
PAIR0038941	Expression	Up-regulation	Western blot analysis	.
PAIR0038942	Expression	Up-regulation	Western blot analysis	.
PAIR0038943	Expression	Down-regulation	Western blot analysis	.
PAIR0038944	Expression	Up-regulation	qRT-PCR	.
PAIR0038945	Expression	Up-regulation	Western blot analysis	NOD-like receptor signaling pathway (+|hsa04621); Neutrophil extracellular trap formation (+|hsa04613)
PAIR0038946	Expression	Up-regulation	Western blot analysis	NOD-like receptor signaling pathway (+|hsa04621); Neutrophil extracellular trap formation (+|hsa04613)
PAIR0038947	Expression	Up-regulation	qRT-PCR	.
PAIR0038948	Expression	Up-regulation	qRT-PCR	.
PAIR0038949	Expression	Up-regulation	Western blot analysis	.
PAIR0038950	Expression	Up-regulation	Western blot analysis	.
PAIR0038951	Lactylation	H3K19la	Western blot analysis	.
PAIR0038952	Expression	Up-regulation	Western blot analysis	.
PAIR0038953	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038954	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038955	Expression	Up-regulation	qRT-PCR; Western blot analysis	Biosynthesis of cofactors (+|hsa01240); p53 signaling pathway (+|hsa04115)
PAIR0038956	Expression	Up-regulation	qRT-PCR; Western blot analysis	Biosynthesis of cofactors (+|hsa01240); p53 signaling pathway (+|hsa04115)
PAIR0038957	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038958	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038959	Expression	Up-regulation	qRT-PCR; Western blot analysis	Biosynthesis of cofactors (+|hsa01240); p53 signaling pathway (+|hsa04115)
PAIR0038960	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038961	Expression	Up-regulation	qRT-PCR	Central carbon metabolism in cancer (+|hsa05230); Glutamatergic synapse (+|hsa04724)
PAIR0038962	Expression	Up-regulation	qRT-PCR; Western blot analysis	Biosynthesis of terpenoids and steroids (+|hsa01062); Indole diterpene alkaloid biosynthesis (+|hsa00403)
PAIR0038963	Expression	Up-regulation	.	mTOR signaling pathway (+|hsa04150); AMPK signaling pathway (+|hsa04152); Insulin signaling pathway (+|hsa04910)
PAIR0038964	Expression	Up-regulation	.	mTOR signaling pathway (+|hsa04150); AMPK signaling pathway (+|hsa04152); Insulin signaling pathway (+|hsa04910)
PAIR0038965	Expression	Up-regulation	ScRNA-seq	EGFR tyrosine kinase inhibitor resistance (+|hsa01521); Alcoholic liver disease (+|hsa04936)
PAIR0038966	Expression	Up-regulation	Western blot analysis	.
PAIR0038967	Expression	Up-regulation	ScRNA-seq	EGFR tyrosine kinase inhibitor resistance (+|hsa01521); Alcoholic liver disease (+|hsa04936)
PAIR0038968	Expression	Up-regulation	ScRNA-seq	EGFR tyrosine kinase inhibitor resistance (+|hsa01521); Alcoholic liver disease (+|hsa04936)
PAIR0038969	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038970	Expression	Up-regulation	qRT-PCR; Western blot analysis	Alcoholic liver disease (+|hsa04936); Fatty acid metabolism (+|hsa01212)
PAIR0038971	Expression	Up-regulation	qRT-PCR; Western blot analysis	Alcoholic liver disease (+|hsa04936); Fatty acid metabolism (+|hsa01212)
PAIR0038972	Expression	Up-regulation	Western blot analysis	.
PAIR0038973	Mutation	.	Western blot analysis	.
PAIR0038974	Expression	Up-regulation	qRT-PCR	.
PAIR0038975	Expression	Up-regulation	Western blot analysis; LC/MS	IL-17 signaling pathway (+|hsa04657); EGFR tyrosine kinase inhibitor resistance (+|hsa01521)
PAIR0038976	Expression	Up-regulation	qRT-PCR	.
PAIR0038977	Expression	Up-regulation	ChIP and western blot	IL-17 signaling pathway (+|hsa04657); EGFR tyrosine kinase inhibitor resistance (+|hsa01521)
PAIR0038978	Expression	Up-regulation	Western blot analysis; LC/MS	IL-17 signaling pathway (+|hsa04657); EGFR tyrosine kinase inhibitor resistance (+|hsa01521)
PAIR0038979	Expression	Up-regulation	Western blot analysis; LC/MS	IL-17 signaling pathway (+|hsa04657); EGFR tyrosine kinase inhibitor resistance (+|hsa01521)
PAIR0038980	Expression	Up-regulation	Western blot analysis; LC/MS	IL-17 signaling pathway (+|hsa04657); EGFR tyrosine kinase inhibitor resistance (+|hsa01521)
PAIR0038981	Expression	Up-regulation	Real time PCR	HIF-1 signaling pathway (+|hsa04066)
PAIR0038982	Expression	Down-regulation	Gene set enrichment analysis	.
PAIR0038983	Expression	Down-regulation	qRT-PCR	.
PAIR0038984	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038985	Expression	Up-regulation	ChIP and western blot	IL-17 signaling pathway (+|hsa04657); EGFR tyrosine kinase inhibitor resistance (+|hsa01521)
PAIR0038986	Expression	Up-regulation	Western blot analysis	.
PAIR0038987	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038988	Expression	Up-regulation	Western blot analysis	.
PAIR0038989	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038990	Expression	Down-regulation	qRT-PCR; Western blot analysis	.
PAIR0038991	Activity	activation	FRET-based high content imaging	.
PAIR0038992	Expression	Up-regulation	ChIP and western blot	IL-17 signaling pathway (+|hsa04657); EGFR tyrosine kinase inhibitor resistance (+|hsa01521)
PAIR0038993	Expression	Down-regulation	Gene set enrichment analysis	.
PAIR0038994	Expression	Up-regulation	Real time PCR	HIF-1 signaling pathway (+|hsa04066)
PAIR0038995	Expression	Up-regulation	ChIP and western blot	IL-17 signaling pathway (+|hsa04657); EGFR tyrosine kinase inhibitor resistance (+|hsa01521)
PAIR0038996	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038997	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0038998	Expression	Up-regulation	qRT-PCR	.
PAIR0038999	Expression	Up-regulation	Western blot analysis	.
PAIR0039000	Activity	inhibit	FRET-based high content imaging	.
PAIR0039001	Expression	Up-regulation	Gene expression profiles	.
PAIR0039002	Expression	Up-regulation	Gene expression profiles	.
PAIR0039003	Expression	Up-regulation	LC-MS/MS	Human immunodeficiency virus 1 infection (+|hsa05170); MAPK signaling pathway (+|hsa04010)
PAIR0039004	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039005	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039006	Expression	Up-regulation	Expression profiles	.
PAIR0039007	Expression	Up-regulation	qRT-PCR; Western blot analysis	HIF-1 signaling pathway (+|hsa04066)
PAIR0039008	Expression	Up-regulation	Expression profiles	.
PAIR0039009	Expression	Up-regulation	qRT-PCR; Western blot analysis	HIF-1 signaling pathway (+|hsa04066)
PAIR0039010	Expression	Down-regulation	qRT-PCR	.
PAIR0039011	Expression	Up-regulation	qRT-PCR	.
PAIR0039012	Expression	Up-regulation	qRT-PCR 	Breast cancer (+|hsa05224); Wnt signaling pathway (+|hsa04310); Adherens junction (+|hsa04520)
PAIR0039013	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0039014	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0039015	Expression	Down-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0039016	Expression	Up-regulation	Expression profiles	.
PAIR0039017	Expression	Up-regulation	Expression profiles	.
PAIR0039018	Expression	Up-regulation	Real-time PCR	.
PAIR0039019	Expression	Up-regulation	Real-time PCR	.
PAIR0039020	Expression	Up-regulation	Western blot analysis	.
PAIR0039021	Expression	Up-regulation	Western blot analysis	.
PAIR0039022	Expression	Up-regulation	.	.
PAIR0039023	Expression	Up-regulation	.	.
PAIR0039024	Expression	Up-regulation	Western blot analysis	.
PAIR0039025	Expression	Down-regulation	Western blot analysis	.
PAIR0039026	Expression	Up-regulation	Western blot analysis	.
PAIR0039027	Expression	Down-regulation	qRT-PCR; Western blot analysis	.
PAIR0039028	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039029	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039030	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039031	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039032	Expression	Up-regulation	DNA-binding assays	.
PAIR0039033	Expression	Up-regulation	DNA-binding assays	.
PAIR0039034	Expression	Up-regulation	Western blot analysis	.
PAIR0039035	Expression	Up-regulation	Western blot analysis	.
PAIR0039036	Activity	activation	Western blot analysis	.
PAIR0039037	Activity	activation	Western blot analysis	.
PAIR0039038	Activity	activation	Western blot analysis	.
PAIR0039039	Activity	activation	Western blot analysis	.
PAIR0039040	Expression	Up-regulation	RNA seq; Western blot analysis	.
PAIR0039041	Expression	Up-regulation	RNA seq; Western blot analysis	.
PAIR0039042	Expression	Up-regulation	.	Human papillomavirus infection (+|hsa05165)
PAIR0039043	Expression	Up-regulation	.	Human papillomavirus infection (+|hsa05165)
PAIR0039044	Expression	Down-regulation	.	Human papillomavirus infection (+|hsa05165)
PAIR0039045	Expression	Up-regulation	.	Human papillomavirus infection (+|hsa05165)
PAIR0039046	Expression	Up-regulation	Whole-transcriptome expression array	.
PAIR0039047	Expression	Up-regulation	qRT-PCR	.
PAIR0039048	Expression	Up-regulation	qRT-PCR	.
PAIR0039049	Expression	Down-regulation	qRT-PCR; Western blot analysis	.
PAIR0039050	Expression	Up-regulation	Western blot analysis	.
PAIR0039051	Expression	Up-regulation	Western blot analysis	.
PAIR0039052	Expression	Up-regulation	Mitochondrial morphology assay; Mitophagy colocalization assay; Western blot analysis	.
PAIR0039053	Expression	Up-regulation	RT-qPCR	.
PAIR0039054	Expression	Up-regulation	Western blot analysis	.
PAIR0039055	Expression	Up-regulation	Mitochondrial morphology assay; Mitophagy colocalization assay; Western blot analysis	.
PAIR0039056	Expression	Up-regulation	Western blot analysis	.
PAIR0039057	Lactylation	K76	Liquid chromatography?mass spectrometry (LC?MS)	.
PAIR0039058	Expression	Up-regulation	RT-qPCR	.
PAIR0039059	Lactylation	K76	Liquid chromatography?mass spectrometry (LC?MS)	.
PAIR0039060	Expression	Down-regulation	RT-qPCR	.
PAIR0039061	Lactylation	H3K18la	Western blot analysis	.
PAIR0039062	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039063	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039064	Lactylation	H3K18la	Western blot analysis	.
PAIR0039065	Lactylation	H3K18la	Western blot analysis	.
PAIR0039066	Lactylation	H3K18la	Western blot analysis	.
PAIR0039067	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039068	Phosphorylation	Down-regulation	qRT-PCR; Western blot analysis	.
PAIR0039069	Expression	Down-regulation	Western blot analysis	TNF signaling pathway (+|hsa04668); Insulin signaling pathway (+|hsa04910)
PAIR0039070	Expression	Down-regulation	qRT-PCR; Western blot analysis	Biosynthesis of secondary metabolites (+|hsa01110)
PAIR0039071	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039072	Expression	Up-regulation	Western blot analysis	.
PAIR0039073	Mutation	.	.	.
PAIR0039074	Expression	Down-regulation	Western blot analysis	.
PAIR0039075	Expression	Up-regulation	Western blot analysis	.
PAIR0039076	Mutation	.	LC-MS	.
PAIR0039077	Expression	Down-regulation	Gene set enrichment analysis	.
PAIR0039078	Expression	Up-regulation	Western blot analysis	.
PAIR0039079	Expression	Up-regulation	Western blot analysis	.
PAIR0039080	Mutation	.	LC-MS	.
PAIR0039081	.	.	.	.
PAIR0039082	.	.	.	.
PAIR0039083	.	.	.	.
PAIR0039084	.	.	.	.
PAIR0039085	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039086	Expression	Down-regulation	Western blot analysis	.
PAIR0039087	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0039088	Expression	Up-regulation	Proteomics	.
PAIR0039089	Expression	Up-regulation	qRT-PCR	Terpenoid backbone biosynthesis (+|hsa00900)
PAIR0039090	Expression	Up-regulation	qRT-PCR	Terpenoid backbone biosynthesis (+|hsa00900)
PAIR0039091	Expression	Up-regulation	qRT-PCR; Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0039092	Autophosphorylation	T172	Western blot analysis	.
PAIR0039093	Autophosphorylation	S473	Western blot analysis	.
PAIR0039094	.	.	.	PI3K-Akt signaling pathway (+|hsa04151)
PAIR0039095	Expression	Up-regulation	qPCR	.
PAIR0039096	Expression	Up-regulation	qPCR	.
PAIR0039097	Expression	Up-regulation	qRT-PCR	.
PAIR0039098	Autophosphorylation	Thr288	Western blot analysis	.
PAIR0039099	Autophosphorylation	Thr288	Western blot analysis	.
PAIR0039100	Expression	Down-regulation	Western blot analysis	.
PAIR0039101	Expression	Down-regulation	Western blot analysis	.
PAIR0039102	Activity	activation	Western blot analysis	.
PAIR0039103	Activity	activation	Western blot analysis	.
PAIR0039104	Expression	Up-regulation	Western blot analysis	.
PAIR0039105	Expression	Up-regulation	qRT-PCR	.
PAIR0039106	Expression	Up-regulation	qRT-PCR	.
PAIR0039107	Expression	Up-regulation	Western blot analysis	.
PAIR0039108	Expression	Up-regulation	Western blot analysis	.
PAIR0039109	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039110	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039111	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039112	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039113	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039114	Mutation	.	.	.
PAIR0039115	.	.	.	.
PAIR0039116	.	.	.	.
PAIR0039117	.	.	.	.
PAIR0039118	.	.	.	.
PAIR0039119	Mutation	.	.	Hippo signaling pathway (+|hsa04390); Insulin signaling pathway (+|hsa04910)
PAIR0039120	Mutation	.	.	Hippo signaling pathway (+|hsa04390); Insulin signaling pathway (+|hsa04910)
PAIR0039121	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039122	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039123	Mutation	.	LC-MS	.
PAIR0039124	Mutation	.	LC-MS	.
PAIR0039125	Mutation	.	LC-MS	.
PAIR0039126	Mutation	.	LC-MS	.
PAIR0039127	Expression	Up-regulation	qRT-PCR; Western blot analysis	TGF-beta signaling pathway (+|hsa04350)
PAIR0039128	Expression	Up-regulation	qRT-PCR; Western blot analysis	TGF-beta signaling pathway (+|hsa04350)
PAIR0039129	Expression	Up-regulation	qRT-PCR; Western blot analysis	TGF-beta signaling pathway (+|hsa04350)
PAIR0039130	Expression	Up-regulation	qRT-PCR; Western blot analysis	TGF-beta signaling pathway (+|hsa04350)
PAIR0039131	Expression	Up-regulation	qRT-PCR; Western blot analysis	TGF-beta signaling pathway (+|hsa04350)
PAIR0039132	Expression	Up-regulation	Western blot analysis	.
PAIR0039133	Expression	Up-regulation	Western blot analysis	.
PAIR0039134	Expression	Up-regulation	qRT-PCR	Terpenoid backbone biosynthesis (+|hsa00900)
PAIR0039135	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039136	Expression	Up-regulation	Western blot analysis	Adrenergic signaling in cardiomyocytes (+|hsa04261)
PAIR0039137	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039138	Expression	Up-regulation	Western blot analysis	.
PAIR0039139	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039140	Expression	Up-regulation	LC-MS	.
PAIR0039141	Expression	Up-regulation	LC-MS	.
PAIR0039142	Expression	Up-regulation	qRT-PCR; Western blot analysis	.
PAIR0039143	Expression	Up-regulation	Western blot analysis	JAK-STAT signaling pathway (+|hsa04630); Insulin resistance (+|hsa04931)
PAIR0039144	Expression	Down-regulation	qRT-PCR and western blotting	.
PAIR0039145	Expression	Up-regulation	Western blot analysis and immunohistochemical assays	Cholesterol metabolism (+|hsa04979)
PAIR0039146	Expression	Up-regulation	Western blot analysis and immunohistochemical assays	Cholesterol metabolism (+|hsa04979)
PAIR0039147	Expression	Down-regulation	RNA sequencing	.
PAIR0039148	Expression	Up-regulation	Transcriptome sequencing and analysis	.
PAIR0039149	Expression	Up-regulation	Transcriptome sequencing and analysis	.
PAIR0039150	Expression	Up-regulation	"qPCR, immunoblot and confocal microscopy approaches"	.
PAIR0039151	Lactylation	K70	Mass spectrometry analysis	.
PAIR0039152	Lactylation	K70	Mass spectrometry analysis	.
PAIR0039153	Lactylation	K70	Mass spectrometry analysis	.
PAIR0039154	Lactylation	K70	Mass spectrometry analysis	.
PAIR0039155	Lactylation	H3K18la	Western blot analysis	.
PAIR0039156	Lactylation	H3K18la	Western blot analysis	.
PAIR0039157	Lactylation	H3K18la	Western blot analysis	.
PAIR0039158	Lactylation	H3K18la	Western blot analysis	.
PAIR0039159	Lactylation	H3K18la	Western blot analysis	.
PAIR0039160	Lactylation	H3K18la	Western blot analysis	.
PAIR0040000	Expression	Up-regulation	qRT-PCR	.
PAIR0040001	Expression	Up-regulation	qRT-PCR	.
PAIR0040002	Expression	Up-regulation	qRT-PCR	.
PAIR0040003	Expression	.	.	.
PAIR0040004	Expression	Down-regulation	Western blot assay	ER stress signalling pathway
PAIR0040005	Expression	Down-regulation	Western blot assay	ER stress signalling pathway
PAIR0040006	Missense mutation	L38HL	PCR; PCR-ELISA assay; GeneSeq assay	.
PAIR0040007	Mutations	G667C; F589L-G595R	Immunofluorescence staining assay; Western blot assay	GGH signaling pathway
PAIR0040008	Expression	Down-regulation	qRT-PCR	Cell autophagy (-|hsa04140)
PAIR0040009	Expression	Up-regulation	Western blot assay	.
PAIR0040010	Expression	Up-regulation	Western blot assay	.
PAIR0040011	Expression	Up-regulation	ELISA assay	.
PAIR0040012	Mutation	.	.	MAPK-RSKs-YB-1 signaling pathway
PAIR0040013	Expression	Up-regulation	qRT-PCR	.
PAIR0040014	Expression	Down-regulation	qRT-PCR	.
PAIR0040015	Expression	Down-regulation	qRT-PCR	.
PAIR0040016	Expression	Up-regulation	qRT-PCR; Western blot assay	.
PAIR0040017	Missense mutation	c.421C>A (rs2231142)	GeneSeq assay; PCR	.
PAIR0040018	Expression	Down-regulation	RT-qPCR; Western blot assay	.
PAIR0040019	Methylation	Down-regulation	PCR; Docking assay	.
PAIR0040020	Mutations	Y107N+S129L 	Genetic cross assay; Bulk segregant analysis; Progeny cloning assay	.
PAIR0040021	Missense mutation	A2059G	GeneSeq assay; PCR	.
PAIR0040022	Mutation	A1518/1519	.	.
PAIR0040023	Mutation	A1518/1519	.	.
PAIR0040024	Expression	Up-regulation	.	Rap1 signaling pathway (+|hsa04015); HIF-1 signaling pathway (+|hsa04066); JAK-STAT signaling pathway (+|hsa04630)
PAIR0040025	Epigenetic modification	Up-regulation	qRT-PCR	.
PAIR0040026	Expression	Up-regulation	qRT-PCR	NR6A1/DNMT3A signaling pathway
PAIR0040027	Expression	Up-regulation	qRT-PCR	DNMT3A signaling pathway
PAIR0040028	Expression	Up-regulation	Gene expression analysis	.
PAIR0040029	Expressiom	D1194A+R1181K+D1194G	.	.
PAIR0040030	Expression	Up-regulation	.	Rap1 signaling pathway (+|hsa04015); HIF-1 signaling pathway (+|hsa04066); JAK-STAT signaling pathway (+|hsa04630)
PAIR0040031	Expressiom	T1080S	.	.
PAIR0040032	Expression	Down-regulation	Western blot assay; qRT-PCR	Aerobic glycolysis signaling pathway; mitochondrial respiration signaling pathway
PAIR0040033	Expression	Up-regulation	Western blot assay; qRT-PCR	Aerobic glycolysis signaling pathway; mitochondrial respiration signaling pathway
PAIR0040034	Phosphorylation	Up-regulation	Protein component assay; Western blot assay	EGFR signaling pathway (-|hsa01521)
PAIR0040035	Expression	Up-regulation	MS analysis; Western blot assay; Immunohistochemistry	"Aerobic glycolysis signaling pathway; Glycine, serine and threonine metabolism (+|hsa00260)"
PAIR0040036	Expression	Activation	MS analysis; Western blot assay; Immunohistochemistry	Aerobic glycolysis signaling pathway; HIF1alpha stabilization signaling pathway
PAIR0040037	Expression	Up-regulation	MS analysis; Western blot assay; Immunohistochemistry	Aerobic glycolysis signaling pathway; FGFR/AKT/ERK signaling pathway
PAIR0040038	Expression	Up-regulation	MS analysis; Western blot assay; Immunohistochemistry	HIF1alpha stabilization signaling pathway
PAIR0040039	Expression	Up-regulation	Western blot assay	Aerobic glycolysis signaling pathway
PAIR0040040	Expression	Up-regulation	Western blot assay	Aerobic glycolysis signaling pathway
PAIR0040041	Expression	Up-regulation	Western blot assay	Aerobic glycolysis signaling pathway
PAIR0040042	phosphorylation	Down-regulation	Western blot assay	.
PAIR0040043	phosphorylation	Up-regulation	Western blot assay	.
PAIR0040044	Phosphorylation	Up-regulation	Western blot assay	.
PAIR0040045	Phosphorylation	Up-regulation	Western blot assay	.
PAIR0040046	Expression	.	.	.
PAIR0040047	Expressiom	D538G+Y537S+Y537N+E380Q	.	.
PAIR0040048	Methylation	Down-regulation	PCR; Docking assay	.
PAIR0040049	Expression	.	.	.
PAIR0040050	Expression	Up-regulation	.	Rap1 signaling pathway (+|hsa04015); HIF-1 signaling pathway (+|hsa04066); JAK-STAT signaling pathway (+|hsa04630)
PAIR0040051	Expression	Down-regulation	Western blot assay; qRT-PCR	PI3K/AKT/mTOR signaling pathway (-|hsa04151)
PAIR0040052	Phosphorylation	Down-regulation	Western blot assay; qRT-PCR	PI3K/AKT/mTOR signaling pathway (-|hsa04151)
PAIR0040053	Expression	Down-regulation	Western blot assay; qRT-PCR	PI3K/AKT/mTOR signaling pathway (-|hsa04151)
PAIR0040054	Phosphorylation	Down-regulation	Western blot assay; qRT-PCR	PI3K/AKT/mTOR signaling pathway (-|hsa04151)
PAIR0040055	Phosphorylation	Up-regulation	Western blot assay; qRT-PCR	PI3K/AKT/mTOR signaling pathway (-|hsa04151)
PAIR0040056	Expression	Up-regulation	Western blot assay; qRT-PCR	PI3K/AKT/mTOR signaling pathway (-|hsa04151)
PAIR0040057	Phosphorylation	Up-regulation	Western blot assay; qRT-PCR	PI3K/AKT/mTOR signaling pathway (-|hsa04151)
PAIR0040058	Expression	Up-regulation	.	PTEN/AKT/beta-catenin/ABCG2 signaling pathway
PAIR0040059	Expression	Up-regulation	Western blot assay	Hedgehog signaling pathway (+|hsa04340)
PAIR0040060	Expression	Down-regulation	Western blot assay	Hedgehog signaling pathway (+|hsa04340)
PAIR0040061	Expression	Down-regulation	Western blot assay	Hedgehog signaling pathway (+|hsa04340)
PAIR0040062	Expression	Down-regulation	Western blot assay	Hedgehog signaling pathway (+|hsa04340)
PAIR0040063	Methylation	Down-regulation	Western blot assay	.
PAIR0040064	Methylation	Up-regulation	Western blot assay	.
PAIR0040065	Expression	Up-regulation	Western blot assay; qRT-PCR	.
PAIR0040066	Expression	Down-regulation	.	.
PAIR0040067	Expression	Down-regulation	.	.
PAIR0040068	Expression	D835Y	.	.
PAIR0040069	phosphorylation	Up-regulation	Western blot assay	.
PAIR0040070	Missense mutation	Exon 20 insertion mutations	GeneSeq assay	PI3K-Akt signaling pathway (-|hsa04151)
PAIR0040071	Mutation	.	.	.
PAIR0040072	Missense mutation	Exon 20 insertion mutations	GeneSeq assay	PI3K-Akt signaling pathway (-|hsa04151)
PAIR0040073	Expression	Up-regulation	Western blot assay	.
PAIR0040074	Mutation	F652L	Genotyping assay	.
PAIR0040075	Mutation	Q24K+L28M+R30E+A92K 	Genotyping assay	.
PAIR0040076	Mutation	Y132F	Genotyping assay	.
PAIR0040077	Expression	Up-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040078	Expression	Down-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040079	Expression	Up-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040080	Expression	.	.	.
PAIR0040081	Expression	Activation	Immunoblotting assay; qRT-PCR; Immunofluorescence staining assay; Reporter Gene assay; RNA sequencing assay	NF+kB signaling pathway (+|hsa04218)
PAIR0040082	Expression	Up-regulation	Immunoblotting assay; qRT-PCR; Immunofluorescence staining assay; Reporter Gene assay; RNA sequencing assay	NF+kB signaling pathway (+|hsa04218)
PAIR0040083	Expression	Up-regulation	Immunoblotting assay; qRT-PCR; Immunofluorescence staining assay; Reporter Gene assay; RNA sequencing assay	NF+kB signaling pathway (+|hsa04218)
PAIR0040084	Function	Up-regulation	Immunoblotting assay; qRT-PCR; Immunofluorescence staining assay; Reporter Gene assay; RNA sequencing assay	NF+kB signaling pathway (+|hsa04218)
PAIR0040085	Expression	Up-regulation	Immunoblotting assay; qRT-PCR; Immunofluorescence staining assay; Reporter Gene assay; RNA sequencing assay	p53 signaling pathway (+|hsa04115)
PAIR0040086	Expression	.	.	.
PAIR0040087	Expression	T1080S+V1062L	.	.
PAIR0040088	Expression	.	.	.
PAIR0040089	Expression	Down-regulation	Western blot assay; qRT-PCR	PI3K/AKT signaling pathway (+|hsa04151)
PAIR0040090	Expression	M2000T	qRT-PCR	.
PAIR0040091	Epigenetic modification	Down-regulation	qRT-PCR	.
PAIR0040092	Expression	Up-regulation	qRT-PCR	NR6A1/DNMT3A signaling pathway
PAIR0040093	Expression	Down-regulation	qRT-PCR	DNMT3A signaling pathway
PAIR0040094	Expression	Up-regulation	qRT-PCR	DNMT3A signaling pathway
PAIR0040095	Expression	Up-regulation	Lipidomics profiling assay; RNA sequencing assay; qRT-PCR; ELISA assay	SPHK1/S1P signaling pathway
PAIR0040096	Expression	Activation	.	HGF-Met signaling pathway
PAIR0040097	Missense mutation	"EGFR-K745_E746insIPVAIK; Exon 19 deletion, L858R, L861Q, G719S, A763_Y764insFQEA"	GeneSeq assay	PI3K-Akt signaling pathway (-|hsa04151)
PAIR0040098	Mutation	.	.	.
PAIR0040099	Missense mutation	"EGFR-K745_E746insIPVAIK; Exon 19 deletion, L858R, L861Q, G719S, A763_Y764insFQEA"	GeneSeq assay	PI3K-Akt signaling pathway (-|hsa04151)
PAIR0040100	phosphorylation	Up-regulation	Western blot assay	.
PAIR0040101	Expression	Up-regulation	Western blot assay	Oxidative stress response signaling pathway
PAIR0040102	Expression	Down-regulation	RT-PCR	.
PAIR0040103	Expression	Up-regulation	RT-PCR	.
PAIR0040104	Expression	Down-regulation	RT-PCR	.
PAIR0040105	Expression	Up-regulation	RT-PCR	.
PAIR0040106	Expression	Up-regulation	RT-PCR	.
PAIR0040107	Expression	Amplification	RT-PCR	.
PAIR0040108	Methylation	Down-regulation	PCR; Docking assay	.
PAIR0040109	Phosphorylation	Up-regulation	.	PI3K/AKT/mTOR signaling pathway (-|hsa04151)
PAIR0040110	Phosphorylation	Up-regulation	.	PI3K/AKT/mTOR signaling pathway (-|hsa04151)
PAIR0040111	Expression	Up-regulation	.	PI3K/AKT/mTOR signaling pathway (-|hsa04151)
PAIR0040112	Expression	Up-regulation	Western blot assay	STAT3 signaling pathway (+|hsa04550); Notch signaling pathway (+|hsa04330)
PAIR0040113	Expression	Up-regulation	Western blot assay; qRT-PCR	.
PAIR0040114	Expression	T227M	.	.
PAIR0040115	Expression	Up-regulation	Western blot assay	p-glycoprotein (p-gp) signaling pathway
PAIR0040116	Expression	Down-regulation	Western blot assay	p-glycoprotein (p-gp) signaling pathway
PAIR0040117	Expression	Up-regulation	Western blot assay; qRT-PCR	.
PAIR0040118	Expression	T790M; C797S	.	.
PAIR0040119	Expression	Up-regulation	RT-qPCR; Glycolysis metabolic enzyme assay; Flow cytometry; Western blot assay; Transcriptome sequencingc assay	PI3K/Akt/mTOR signaling pathway
PAIR0040120	Mutation	.	.	PI3K-Akt signaling pathway (+|hsa04151)
PAIR0040121	Expression	Up-regulation	RT-qPCR; Western blot assay	DNA Damage Response Mechanism (DDR) comprises numerous signaling pathway
PAIR0040122	Expression	Up-regulation	RT-qPCR; Western blot assay	DNA Damage Response Mechanism (DDR) comprises numerous signaling pathway
PAIR0040123	Expression	Up-regulation	RT-qPCR; Western blot assay	DNA Damage Response Mechanism (DDR) comprises numerous signaling pathway
PAIR0040124	Expression	Down-regulation	CD spectroscopy assay; SDS-PAGE assay	.
PAIR0040125	Expression	Up-regulation	CD spectroscopy assay; SDS-PAGE assay	.
PAIR0040126	Expression	Up-regulation	CD spectroscopy assay; SDS-PAGE assay	HER2 signaling pathway (-|hsa04012)
PAIR0040127	Expression	Up-regulation	CD spectroscopy assay; SDS-PAGE assay	.
PAIR0040128	Expression	Up-regulation	Western blot assay	.
PAIR0040129	Expression	Up-regulation	Western blot assay; Immunohistochemistry; Immunofluorescence staining assay	MAPK signaling pathway (-|hsa04010); AKT/mTOR signaling pathway (-|hsa04150)
PAIR0040130	Expression	Down-regulation	RT-qPCR; Western blot assay	.
PAIR0040131	Expression	Up-regulation	PCR	.
PAIR0040132	.	.	.	Wnt/beta-catenin Signalling Pathway
PAIR0040133	Phosphorylation	Up-regulation	Immunoblotting assay	.
PAIR0040134	Expression	p.Y537N	Immunoblotting assay	.
PAIR0040135	Missense mutation	Down-regulation	Immunoblotting assay	Rho GTPases signaling pathway; MAPK signaling pathway (+|hsa04010); WNT/beta-catenin signaling pathway; NOTCH signaling pathway (+|hsa04330)
PAIR0040136	Missense mutation	G42S	RT-PCR; PCR; GeneSeq assay	.
PAIR0040137	Expression	Up-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040138	Expression	Up-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040139	Expression	Down-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040140	Mutation	G307A	Genotyping assay	.
PAIR0040141	Mutation	K444R/E+N450D	Genotyping assay	.
PAIR0040142	Mutation	W1370R	Genotyping assay	.
PAIR0040143	Expression	Ubc7	.	.
PAIR0040144	Expression	Ubc6	.	.
PAIR0040145	Expressiom	Up-regulation	Flow cytometry	.
PAIR0040146	Expressiom	Up-regulation	Flow cytometry	.
PAIR0040147	Expression	Up-regulation	Gene expression analysis	.
PAIR0040148	Expressiom	D96D	.	.
PAIR0040149	Function	RV0005; p.Ala403Ser	PCR; Catalase foam assay; Catalase gel assay	.
PAIR0040150	Expression	Activation	.	HGF-Met signaling pathway
PAIR0040151	Expression	Down-regulation	qRT-PCR	Cell autophagy (-|hsa04140)
PAIR0040152	Expression	Loss	qRT-PCR	Cell autophagy (-|hsa04140)
PAIR0040153	Expression	Down-regulation	qRT-PCR	.
PAIR0040154	Expression	Up-regulation	qRT-PCR	.
PAIR0040155	Expression	Up-regulation	Western blot assay	Ca2+/calcineurin/MEK/ERK1/2 signaling pathway
PAIR0040156	Mutation	.	.	.
PAIR0040157	Expression	Down-regulation	Western blot assay	Cell autophagy (-|hsa04140)
PAIR0040158	Expression	Up-regulation	Western blot assay	Cell autophagy (-|hsa04140)
PAIR0040159	Expression	Up-regulation	Western blot assay; RNA extraction assay; RT-qPCR; DNA sequencing assay	FGFR signaling pathway (+|hsa01521); PI3K/AKT signaling pathway (+|hsa04151); MAPK signaling pathway (+|hsa04010)
PAIR0040160	Expression	Down-regulation	Western blot assay; RNA extraction assay; RT-qPCR; DNA sequencing assay	FGFR signaling pathway (+|hsa01521); PI3K/AKT signaling pathway (+|hsa04151); MAPK signaling pathway (+|hsa04010)
PAIR0040161	Phosphorylation	Up-regulation	Western blot assay; RNA extraction assay; RT-qPCR; DNA sequencing assay	FGFR signaling pathway (+|hsa01521); PI3K/AKT signaling pathway (+|hsa04151); MAPK signaling pathway (+|hsa04010)
PAIR0040162	Expression	Up-regulation	Western blot assay	.
PAIR0040163	Expression	Down-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040164	Expression	Up-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040165	Expression	Up-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040166	Expression	.	.	Cell autophagy (-|hsa04140)
PAIR0040167	Expression	.	.	Cell autophagy (-|hsa04140)
PAIR0040168	Expression	Up-regulation	Western blot assay	.
PAIR0040169	Expression	Up-regulation	Western blot assay	.
PAIR0040170	Expression	Up-regulation	Western blot assay; qRT-PCR	.
PAIR0040171	Expressiom	Down-regulation	Flow cytometry	.
PAIR0040172	Phosphorylation	.	.	.
PAIR0040173	Phosphorylation	.	.	.
PAIR0040174	Expression	Up-regulation	Western blot assay	STAT3 signaling pathway (+|hsa04550); Notch signaling pathway (+|hsa04330)
PAIR0040175	Expression	Down-regulation	Western blot assay	Ferroptosis signaling pathway (+|hsa04216)
PAIR0040176	Expression	Up-regulation	Western blot assay	Ferroptosis signaling pathway (+|hsa04216)
PAIR0040177	Expression	Up-regulation	qPCR; IHC assay	.
PAIR0040178	Expression	Up-regulation	Western blot assay	EREG/ErbB/ERK signalling pathway
PAIR0040179	Methylation	Up-regulation	Western blot assay	.
PAIR0040180	Expression	Up-regulation	Western blot assay; qRT-PCR	Beta-catenin/MGMT signaling pathway
PAIR0040181	Expression	.	.	NEAT1/miR-454-3p/Connexin 43 signaling pathway
PAIR0040182	Expression	Down-regulation	qRT-PCR	Beta-catenin/MGMT signaling pathway
PAIR0040183	Expression	Down-regulation	qRT-PCR	NEAT1/miR-454-3p/Connexin 43 signaling pathway
PAIR0040184	Expression	Up-regulation	Western blot assay	Beta-catenin/MGMT signaling pathway
PAIR0040185	Expression	.	.	NEAT1/miR-454-3p/Connexin 43 signaling pathway
PAIR0040186	Expression	.	.	NEAT1/miR-454-3p/Connexin 43 signaling pathway
PAIR0040187	Expression	Up-regulation	Western blot assay	Cell autophagy (-|hsa04140)
PAIR0040188	Expression	Up-regulation	RT-PCR	RHAMM signaling pathway
PAIR0040189	Expression	Up-regulation	.	.
PAIR0040190	Expression	Up-regulation	qRT-PCR	lncRNA UCA1/miR-30a-3p/PPARalpha signaling pathway
PAIR0040191	Expression	D1194A+A1182V+Q1106K/R+D1194E/T+S1148A/G	.	.
PAIR0040192	Expression	.	.	Cell autophagy (-|hsa04140)
PAIR0040193	Expression	.	.	Cell autophagy (-|hsa04140)
PAIR0040194	Expressiom	L747S	Flow cytometry	.
PAIR0040195	Expression	Up-regulation	qPCR; qRT-PCR	.
PAIR0040196	Expression	Down-regulation	qPCR; qRT-PCR	.
PAIR0040197	Expression	Up-regulation	qPCR; qRT-PCR	.
PAIR0040198	Expression	Down-regulation	qPCR; qRT-PCR	.
PAIR0040199	Expression	Down-regulation	Acetyltransferase assay	.
PAIR0040200	Expression	Up-regulation	Western blot assay; qRT-PCR	.
PAIR0040201	Phosphorylation	Up-regulation	Western blot assay; qRT-PCR	.
PAIR0040202	Expression	Up-regulation	Western blot assay; qRT-PCR	.
PAIR0040203	Phosphorylation	Up-regulation	Western blot assay; qRT-PCR	.
PAIR0040204	Expression	Up-regulation	Western blot assay; qRT-PCR	.
PAIR0040205	Expression	Up-regulation	Western blot assay	.
PAIR0040206	Mutation	K444R/E+N450D	.	.
PAIR0040207	Expression	Up-regulation	Western blot assay; Immunohistochemistry	JAK-STAT signaling pathway (+|hsa04630); AKT/mTOR signaling pathway; MAPK signaling pathway (+|hsa04010)
PAIR0040208	Expression	Up-regulation	.	Rap1 signaling pathway (+|hsa04015); HIF-1 signaling pathway (+|hsa04066); JAK-STAT signaling pathway (+|hsa04630)
PAIR0040209	Mutation	I828V	.	.
PAIR0040210	Expression	.	.	.
PAIR0040211	Mutation	Q24K+L28M+R30E+A92K 	GeneSeq assay; Bioinformatics assay	.
PAIR0040212	Mutation	R173C	GeneSeq assay; Bioinformatics assay	.
PAIR0040213	Mutations	Q24K+L28M+R30E+A92K 	Microarray assay	.
PAIR0040214	Expressiom	Down-regulation	.	.
PAIR0040215	Deletion mutation	.	.	.
PAIR0040216	Expressiom	Up-regulation	.	.
PAIR0040217	Expressiom	Down-regulation	.	.
PAIR0040218	Mutations	.	Long-term passaging assay; Molecular clones assay	.
PAIR0040219	Mutantion	p.R183W	.	.
PAIR0040220	Expression	Up-regulation	Immunoblotting assay; qPCR	.
PAIR0040221	Mutantion	p.Y537N	.	.
PAIR0040222	Expression	Down-regulation	GeneSeq assay; Western blot assay	.
PAIR0040223	Mutantion	p.R58X	.	.
PAIR0040224	Expression	Down-regulation	qRT-PCR	EGFR/HER2 signaling pathway
PAIR0040225	Phosphorylation	Down-regulation	Western blot assay	EGFR/HER2 signaling pathway
PAIR0040226	Expression	Up-regulation	qRT-PCR	EGFR/HER2 signaling pathway
PAIR0040227	Expression	Up-regulation	Western blot assay	EGFR/HER2 signaling pathway
PAIR0040228	Phosphorylation	Up-regulation	Western blot assay	EGFR/HER2 signaling pathway
PAIR0040229	Expression	Up-regulation	qRT-PCR	EGFR/HER2 signaling pathway
PAIR0040230	Expression	Down-regulation	Western blot assay	EGFR/HER2 signaling pathway
PAIR0040231	Phosphorylation	Down-regulation	Western blot assay	EGFR/HER2 signaling pathway
PAIR0040232	Expression	Down-regulation	Immunoblotting assay	.
PAIR0040233	Expression	Up-regulation	RT-PCR	NF-kB signaling pathway (+|hsa04218)
PAIR0040234	Expression	Up-regulation	Western blot assay	NF-kB signaling pathway (+|hsa04218)
PAIR0040235	Expression	Up-regulation	RT-PCR	NF-kB signaling pathway (+|hsa04218)
PAIR0040236	Expression	Up-regulation	Western blot assay	NF-kB signaling pathway (+|hsa04218)
PAIR0040237	Expression	Up-regulation	Gene expression analysis	.
PAIR0040238	Expression	Up-regulation	Gene expression analysis	.
PAIR0040239	Expression	.	qPCR	.
PAIR0040240	Expression	.	qPCR	.
PAIR0040241	Mutation	Q24K+L28M+R30E+A92K 	GeneSeq assay; Bioinformatics assay	.
PAIR0040242	Expressiom	Down-regulation	.	.
PAIR0040243	Missense mutation	A98G+K103N+P225H	PCR; Catalase foam assay; Catalase gel assay	.
PAIR0040244	Expression	Up-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040245	Expression	Down-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040246	Expression	Up-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040247	Expression	Up-regulation	Gene expression analysis	.
PAIR0040248	Expression	Down-regulation	RT-PCR; Immunofluorescence staining assay	.
PAIR0040249	Expression	Up-regulation	RT-PCR; Immunofluorescence staining assay	.
PAIR0040250	Expression	Down-regulation	RT-PCR; Immunofluorescence staining assay	.
PAIR0040251	Expression	Up-regulation	RT-PCR; Immunofluorescence staining assay	.
PAIR0040252	Expression	Down-regulation	Western blot assay	MAPK signaling pathway (+|hsa04010)
PAIR0040253	Expression	Up-regulation	qRT-PCR	.
PAIR0040254	Expression	Up-regulation	Western blot assay; qRT-PCR	.
PAIR0040255	Expression	Down-regulation	qRT-PCR	PLK1 regulatory signalling pathway; Cell cycle (+|hsa04110)
PAIR0040256	Expression	Up-regulation	Western blot assay	Ca2+/calcineurin/MEK/ERK1/2 signaling pathway
PAIR0040257	Missense mutation	Exon 20 insertion mutations	GeneSeq assay	PI3K-Akt signaling pathway (-|hsa04151)
PAIR0040258	Phosphorylation	Up-regulation	Western blot assay; Immunofluorescence staining assay; Immunohistochemistry; RNA sequencing assay	PI3K+Akt signaling pathway (+|hsa04151)
PAIR0040259	Expression	Down-regulation	Western blot assay; Immunofluorescence staining assay; Immunohistochemistry; RNA sequencing assay	PI3K+Akt signaling pathway (+|hsa04151)
PAIR0040260	Expression	Down-regulation	Western blot assay; Immunofluorescence staining assay; Immunohistochemistry; RNA sequencing assay	PI3K+Akt signaling pathway (+|hsa04151)
PAIR0040261	Expression	Down-regulation	Western blot assay	Ca2+/calcineurin/MEK/ERK1/2 signaling pathway
PAIR0040262	Mutation	.	.	.
PAIR0040263	Missense mutation	Exon 20 insertion mutations	GeneSeq assay	PI3K-Akt signaling pathway (-|hsa04151)
PAIR0040264	Expression	.	.	.
PAIR0040265	Expression	Up-regulation	Gene expression analysis	.
PAIR0040266	Expression	Down-regulation	RNA sequencing assay; Whole-exome sequencing assay; qRT-PCR; Western blot assay; ELISA assay	.
PAIR0040267	Expression	Up-regulation	qPCR; Protein degradation assay; Proteasome inhibition assay; Western blot assay; Proximity-labeling assay; MS analysis	.
PAIR0040268	Missense mutation	A1182V	PCR; Southern blot assay	.
PAIR0040269	Missense mutation	A1518/1519	Primer extension analysis; MS analysis; Western blot assay; Semiquantitative RT-PCR	.
PAIR0040270	Expression	Up-regulation	Western blot assay; qRT-PCR	Ras/p53/JAK/PI3K signaling pathway
PAIR0040271	Expression	Up-regulation	Western blot assay	.
PAIR0040272	Expression	Up-regulation	.	.
PAIR0040273	Expression	Up-regulation	Western blot assay; qRT-PCR	Downstream AR signaling pathway
PAIR0040274	Expression	Up-regulation	Reactive oxygen species measurement assay; Mitochondrial membrane potential measurement assay; CD spectroscopy assay; DNA interaction assay; qRT-PCR; Western blot assay	Apoptosis signaling pathway (+|hsa04210)
PAIR0040275	Expression	Up-regulation	Reactive oxygen species measurement assay; Mitochondrial membrane potential measurement assay; CD spectroscopy assay; DNA interaction assay; qRT-PCR; Western blot assay	Apoptosis signaling pathway (+|hsa04210)
PAIR0040276	Expression	Down-regulation	qRT-PCR; Western blot assay	Hsa_circ_0072732 /miR-548b-3p/ SLC7A11 signaling pathway
PAIR0040277	Expression	Down-regulation	Western blot assay; qRT-PCR	HIF-1alpha/VEGFA/VEGFR signalling pathway
PAIR0040278	Expression	Down-regulation	Western blot assay; qRT-PCR	HIF-1alpha/VEGFA/VEGFR signalling pathway
PAIR0040279	Expression	Up-regulation	Western blot assay	.
PAIR0040280	Expression	Up-regulation	Western blot assay	.
PAIR0040281	Mutation	Up-regulation	RT-PCR	.
PAIR0040282	Missense mutation	Rv2043c;  p.His57Asp	PCR	.
PAIR0040283	Missense mutation	Rv2780;  c.-32T?>?C	PCR	.
PAIR0040284	Missense mutation	A1182V	PCR; Southern blot assay	.
PAIR0040285	Missense mutation	A1518/1519	Primer extension analysis; MS analysis; Western blot assay; Semiquantitative RT-PCR	.
PAIR0040286	Expression	Up-regulation	.	.
PAIR0040287	Expression	S1148A	.	.
PAIR0040288	Expression	Up-regulation	Western blot assay	.
PAIR0040289	Expression	.	.	.
PAIR0040290	Expression	Up-regulation	Western blot assay	.
PAIR0040291	Expression	Up-regulation	Western blot assay	.
PAIR0040292	Expression	Up-regulation	Western blot assay	.
PAIR0040293	Expression	Up-regulation	Western blot assay	.
PAIR0040294	Expression	Up-regulation	Western blot assay	.
PAIR0040295	Expression	Up-regulation	Western blot assay	.
PAIR0040296	Expression	Up-regulation	qRT-PCR	Beta-catenin/MGMT signaling pathway
PAIR0040297	Expression	Down-regulation	Western blot assay	Beta-catenin/MGMT signaling pathway
PAIR0040298	Expressiom	Down-regulation	Flow cytometry	.
PAIR0040299	Expression	Up-regulation	Western blot assay	.
PAIR0040300	Expression	Up-regulation	Western blot assay	.
PAIR0040301	Expression	Up-regulation	Western blot assay	.
PAIR0040302	Expression	Down-regulation	Western blot assay; qRT-PCR	EGFR signaling pathway (+|hsa01521); HER3 signaling pathway
PAIR0040303	Phosphorylation	Up-regulation	Western blot assay	.
PAIR0040304	Phosphorylation	Up-regulation	Western blot assay	.
PAIR0040305	Expression	.	.	Cell autophagy (-|hsa04140)
PAIR0040306	Expression	.	.	Cell autophagy (-|hsa04140)
PAIR0040307	Expression	Up-regulation	.	Rap1 signaling pathway (+|hsa04015); HIF-1 signaling pathway (+|hsa04066); JAK-STAT signaling pathway (+|hsa04630)
PAIR0040308	Expression	Down-regulation	Western blot assay	STAT3 signaling pathway (+|hsa04550); Notch signaling pathway (+|hsa04330)
PAIR0040309	Expression	Up-regulation	Western blot assay	.
PAIR0040310	Expression	Up-regulation	Western blot assay; qRT-PCR	.
PAIR0040311	Expression	Down-regulation	qRT-PCR	miR-106a-5p/Cyclin D1 signalling pathway
PAIR0040312	Expression	Up-regulation	qRT-PCR	miR-106a-5p/Cyclin D1 signalling pathway
PAIR0040313	Expression	Up-regulation	Western blot assay	Cell autophagy (-|hsa04140)
PAIR0040314	Expression	Up-regulation	Western blot assay	Cell autophagy (-|hsa04140)
PAIR0040315	Phosphorylation	Down-regulation	Immunoprecipitation assay	.
PAIR0040316	O-GlcNAc glycosylation	Up-regulation	Immunoprecipitation assay	.
PAIR0040317	Expression	Up-regulation	Western blot assay	.
PAIR0040318	Expression	Down-regulation	qRT-PCR; Immunoblotting assay	.
PAIR0040319	Expression	Up-regulation	Western blot assay	Retrograde endocannabinoid signaling pathway (-|hsa04723)
PAIR0040320	Expression	Up-regulation	Western blot assay	Retrograde endocannabinoid signaling pathway (-|hsa04723)
PAIR0040321	Expression	Down-regulation	Western blot assay	Retrograde endocannabinoid signaling pathway (-|hsa04723)
PAIR0040322	Expression	Up-regulation	Western blot assay	Retrograde endocannabinoid signaling pathway (-|hsa04723)
PAIR0040323	Function	Up-regulation	MS analysis; Western blot assay; Immunohistochemistry	FGFR/PI3K/AKT signaling pathway; FGFR/RAS/MAPK signaling pathway
PAIR0040324	Expression	Up-regulation	MS analysis; Western blot assay; Immunohistochemistry	Fatty acid biosynthesis signaling pathway (+|hsa00061)
PAIR0040325	Expression	Down-regulation	MS analysis; Western blot assay; Immunohistochemistry	HIF1alpha stabilization signaling pathway
PAIR0040326	Expression	Up-regulation	Western blot assay	Fatty acid biosynthesis (+|hsa00061)
PAIR0040327	Expression	Up-regulation	Western blot assay	Fatty acid biosynthesis (+|hsa00061)
PAIR0040328	Expression	Down-regulation	Western blot assay	Fatty acid biosynthesis (+|hsa00061)
PAIR0040329	phosphorylation	Up-regulation	Western blot assay	.
PAIR0040330	Expression	Up-regulation	.	.
PAIR0040331	Expression	Up-regulation	.	.
PAIR0040332	Expression	Up-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040333	Expression	Up-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040334	Expression	Down-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040335	Phosphorylation	S704	.	PI3K/AKT/mTOR signaling pathway (-|hsa04151)
PAIR0040336	Phosphorylation	T1080S	.	PI3K/AKT/mTOR signaling pathway (-|hsa04151)
PAIR0040337	Expression	Down-regulation	qRT-PCR	PI3K/AKT/mTOR signaling pathway (+|hsa04151)
PAIR0040338	Expression	Up-regulation	Western blot assay	Axl signalling pathway
PAIR0040339	Phosphorylation	Up-regulation	Western blot assay	Axl signalling pathway
PAIR0040340	Mutation	D1194A	WES assay	FLT3-ITD signalling pathway
PAIR0040341	Mutation	Rv1173;  c.-32 A?>?G	WES assay	FLT3-ITD signalling pathway
PAIR0040342	Expression	Down-regulation	RT-qPCR; Western blot assay; RNA immunoprecipitation assay	.
PAIR0040343	Expression	Down-regulation	RT-qPCR; Western blot assay	.
PAIR0040344	Mutation	Q24K/L28M/R30Q/A92K RASs	Cell-Free DNA extraction assay; ddPCR	.
PAIR0040345	Mutation	W780R	Cell-Free DNA extraction assay; ddPCR	.
PAIR0040346	Mutation	E17K	Cell-Free DNA extraction assay; ddPCR	.
PAIR0040347	Mutation	Q24K/L28M/R30Q/A92K RASs	Cell-Free DNA extraction assay; ddPCR	.
PAIR0040348	Interaction	K143R?	Whole exome sequencing assay; Western blot assay; Akt activity assay; 3D foci assay; Phosphorylation pathway analysis; Gene enrichment assay; Network analysis; Functional enrichment analysis	MAPK signaling pathway (+|hsa04010)
PAIR0040349	Function	Activation	Whole exome sequencing assay; Western blot assay; Akt activity assay; 3D foci assay; Phosphorylation pathway analysis; Gene enrichment assay; Network analysis; Functional enrichment analysis	PI3Kalpha and beta1 integrin signaling pathway
PAIR0040350	Expression	Down-regulation	Whole exome sequencing assay; Western blot assay; Akt activity assay; 3D foci assay; Phosphorylation pathway analysis; Gene enrichment assay; Network analysis; Functional enrichment analysis	MAPK signaling pathway (+|hsa04010)
PAIR0040351	Phosphorylation	Down-regulation	Whole exome sequencing assay; Western blot assay; Akt activity assay; 3D foci assay; Phosphorylation pathway analysis; Gene enrichment assay; Network analysis; Functional enrichment analysis	PI3K/AKT signaling pathway (-|hsa04151)
PAIR0040352	Phosphorylation	Down-regulation	Whole exome sequencing assay; Western blot assay; Akt activity assay; 3D foci assay; Phosphorylation pathway analysis; Gene enrichment assay; Network analysis; Functional enrichment analysis	PI3K/AKT signaling pathway (-|hsa04151)
PAIR0040353	Phosphorylation	Down-regulation	Whole exome sequencing assay; Western blot assay; Akt activity assay; 3D foci assay; Phosphorylation pathway analysis; Gene enrichment assay; Network analysis; Functional enrichment analysis	PI3K/AKT signaling pathway (-|hsa04151)
PAIR0040354	Double-insertion mutation	L2003V+Q2002H+M2000T+Y2065N+NL2003M+L2003M	Trajectory assay	.
PAIR0040355	Expression	Up-regulation	qRT-PCR	HGF-Met signaling pathway
PAIR0040356	Missense mutation	A2058G	GeneSeq assay; PCR	.
PAIR0040357	Phosphorylation	.	.	.
PAIR0040358	Phosphorylation	.	.	.
PAIR0040359	Expression	Up-regulation	qPCR; IHC assay	.
PAIR0040360	Expression	Down-regulation	qRT-PCR; Immunoblotting assay	.
PAIR0040361	.	.	.	Wnt/beta-catenin Signalling Pathway
PAIR0040362	Expression	Up-regulation	Western blot assay; qRT-PCR	.
PAIR0040363	Expression	Up-regulation	Western blot assay; qRT-PCR	.
PAIR0040364	Mutation	I829V	.	.
PAIR0040365	Missense mutation	Rv0668;  p.Arg69Pro	Immunoprecipitation assay; LC-MS/MS analysis	.
PAIR0040366	Missense mutation	K582I	Immunoprecipitation assay; LC-MS/MS analysis	.
PAIR0040367	Methylation	Up-regulation	Western blot assay	.
PAIR0040368	Expression	Up-regulation	Gene expression analysis	.
PAIR0040369	Expression	.	.	.
PAIR0040370	Expressiom	Down-regulation	.	.
PAIR0040371	Missense mutation	V600E	GeneSeq assay; PCR	.
PAIR0040372	Expression	Up-regulation	Gene expression analysis	.
PAIR0040373	Expression	.	.	.
PAIR0040374	Expression	Down-regulation	Global transcriptome assay	Interferon type I signaling pathway; NF-kB signaling pathway (-|hsa04218)
PAIR0040375	Expression	Up-regulation	Western blot assay; qRT-PCR	.
PAIR0040376	Expression	Up-regulation	qRT-PCR	Cell autophagy (-|hsa04140)
PAIR0040377	Expression	Down-regulation	.	.
PAIR0040378	Mutations	.	Whole exome sequencing assay; Sanger sequencing assay	.
PAIR0040379	Expression	Up-regulation	Western blot assay; GSH assay; MDA assay	SLC7A11/GSH/GPX4 signaling pathway
PAIR0040380	Expression	Up-regulation	Western blot assay	STAT3 signaling pathway (+|hsa04550)
PAIR0040381	Expression	Down-regulation	Western blot assay	STAT3 signaling pathway (+|hsa04550)
PAIR0040382	Expression	Up-regulation	Western blot assay	STAT3 signaling pathway (+|hsa04550)
PAIR0040383	Expression	Up-regulation	Western blot assay	STAT3 signaling pathway (+|hsa04550)
PAIR0040384	Expression	Down-regulation	Western blot assay	STAT3 signaling pathway (+|hsa04550)
PAIR0040385	Expression	Down-regulation	Immunoprecipitation assay; LC-MS/MS analysis	EGF-EGFR signaling pathway
PAIR0040386	Expression	Up-regulation	Western blot assay	EGFR/HER2/IGF1R signaling pathway
PAIR0040387	Expression	Down-regulation	Western blot assay	LDOC1/GNL3L/NFkappaB signalling pathway
PAIR0040388	Expression	Down-regulation	Western blot assay	LDOC1/GNL3L/NFkappaB signalling pathway
PAIR0040389	Expression	Up-regulation	Western blot assay	LDOC1/GNL3L/NFkappaB signalling pathway
PAIR0040390	Expression	Down-regulation	Western blot assay	LDOC1/GNL3L/NFkappaB signalling pathway
PAIR0040391	Expression	.	.	.
PAIR0040392	Expression	.	.	.
PAIR0040393	Missense mutation	A1518/1519	Primer extension analysis; MS analysis; Western blot assay; Semiquantitative RT-PCR	.
PAIR0040394	Expression	Up-regulation	.	AR signalling pathway
PAIR0040395	Expressiom	Down-regulation	.	.
PAIR0040396	.	.	Gene expression analysis	.
PAIR0040397	Expression	Down-regulation	LC-MS/MS analysis; Infrared assay	Phenylalanine and Tyrosine metabolic signaling pathway (+|hsa01100)
PAIR0040398	Expression	Down-regulation	LC-MS/MS analysis; Infrared assay	Phenylalanine and Tyrosine metabolic signaling pathway (+|hsa01100)
PAIR0040399	Expression	Up-regulation	LC-MS/MS analysis; Infrared assay	Phenylalanine and Tyrosine metabolic signaling pathway (+|hsa01100)
PAIR0040400	Expression	Up-regulation	LC-MS/MS analysis; Infrared assay	Phenylalanine and Tyrosine metabolic signaling pathway (+|hsa01100)
PAIR0040401	Phosphorylation	Down-regulation	RNA sequencing assay; RT-qPCR; Western blot assay	JAK-STAT signaling pathway (-|hsa04630)
PAIR0040402	Expression	Down-regulation	Fluorescence in situ hybridization assay; Small interfering RNA assay; Luciferase reporter assay; Fluorescent qPCR; Western blot assay	.
PAIR0040403	Mutation	R658G	GeneSeq assay; Bioinformatics assay	.
PAIR0040404	.	.	.	Wnt/beta-catenin Signalling Pathway
PAIR0040405	Expressiom	S1148G	.	.
PAIR0040406	Expressiom	S1148R	.	.
PAIR0040407	Expressiom	S2702T	.	.
PAIR0040408	Mutations	E340K	qRT-PCR; Deep sequencing assay	.
PAIR0040409	Mutation	.	.	.
PAIR0040410	Mutations	L100I + K103N + P225H	qRT-PCR; Deep sequencing assay	.
PAIR0040411	Mutations	L2003M	qRT-PCR; Deep sequencing assay	.
PAIR0040412	Single mutations	E802A+E802D+V791I+C799F	Biochemical assay	.
PAIR0040413	Mutations	E484K+F490S+S494P	qRT-PCR; Deep sequencing assay	.
PAIR0040414	Missense mutation	Methylation	GeneSeq assay; Mutation assay	.
PAIR0040415	Missense mutation	Activation	GeneSeq assay; Mutation assay	.
PAIR0040416	Missense mutation	Amplification	GeneSeq assay; Mutation assay	.
PAIR0040417	Missense mutation	Methylation	GeneSeq assay; Mutation assay	.
PAIR0040418	Missense mutation	Loss	GeneSeq assay; Mutation assay	.
PAIR0040419	Missense mutation	p.R183W	GeneSeq assay; Mutation assay	.
PAIR0040420	Function	C2617T/A; A2063G	GeneSeq assay; Mutation assay	.
PAIR0040421	Expression	Down-regulation	Immunoprecipitation assay; LC-MS/MS analysis	Mitochondrial ferroptosis regulatory signaling pathway
PAIR0040422	Expression	Up-regulation	Immunoblotting assay	Src-EphA2-Akt signaling pathway
PAIR0040423	Mutation	Q1106L	Renilla luciferase reporter assay	.
PAIR0040424	Mutation	pAktS473	Renilla luciferase reporter assay	.
PAIR0040425	Mutation	V1196A	.	.
PAIR0040426	Mutation	V1196A	.	.
PAIR0040427	Mutation	V1196A	.	.
PAIR0040428	Mutation	V1196A	.	.
PAIR0040429	Mutations	Q24K/L28M/R30E/A92K RASs	Amino acid substitutions assay	.
PAIR0040430	Substitutions	p.C529Y	Protein sequencing assay	.
PAIR0040431	Expression	Up-regulation	Immunoblotting assay	Src-EphA2-Akt signaling pathway
PAIR0040432	Mutation	Q1106K	Renilla luciferase reporter assay	.
PAIR0040433	Mutation	Q1106L	Renilla luciferase reporter assay	.
PAIR0040434	Mutations	Q24K/L28M/R30E/A92K RASs	Amino acid substitutions assay	.
PAIR0040435	Mutation	Q1106K	Renilla luciferase reporter assay	.
PAIR0040436	Mutation	Q2002H	Renilla luciferase reporter assay	.
PAIR0040437	Mutations	Q24K/L28M/R30E/A92K RASs	Amino acid substitutions assay	.
PAIR0040438	Mutation	Q1106K/R	Renilla luciferase reporter assay	.
PAIR0040439	Mutation	Q2002H	Renilla luciferase reporter assay	.
PAIR0040440	Mutations	Q24K/L28M/R30E/A92K RASs	Amino acid substitutions assay	.
PAIR0040441	Mutation	Q1106K/R	Renilla luciferase reporter assay	.
PAIR0040442	Mutation	Q24K/L28M/R30E/A92K RASs	Renilla luciferase reporter assay	.
PAIR0040443	Mutations	Q24K/L28M/R30Q/A92K RASs	Amino acid substitutions assay	.
PAIR0040444	Expression	Up-regulation	Western blot assay	.
PAIR0040445	Expression	Down-regulation	Western blot assay	.
PAIR0040446	Phosphorylation	Down-regulation	Western blot assay	EGFR/STAT3/ERK signalling pathway
PAIR0040447	Phosphorylation	Down-regulation	Western blot assay	EGFR/STAT3/ERK signalling pathway
PAIR0040448	Phosphorylation	Down-regulation	Western blot assay	EGFR/STAT3/ERK signalling pathway
PAIR0040449	Expression	Down-regulation	Western blot assay	.
PAIR0040450	Mutation	Interaction	.	.
PAIR0040451	Mutation	K103N + V106M	.	.
PAIR0040452	Mutation	K114N	.	.
PAIR0040453	Expression	Up-regulation	Western blot assay	.
PAIR0040454	Mutation	V1196A	.	.
PAIR0040455	Substitutions	Rv0682;  c.-165T?>?C	Protein sequencing assay	.
PAIR0040456	Expression	Up-regulation	Ellman assay	.
PAIR0040457	Expression	Up-regulation	ELISA assay	Nrf2 signaling pathway (-|hsa05208)
PAIR0040458	Mutation	V1196A	.	.
PAIR0040459	Mutation	V1196A	.	.
PAIR0040460	Substitutions	"P225F, N230I, or H272R"	Protein sequencing assay	.
PAIR0040461	Mutation	V1196A	.	.
PAIR0040462	Substitutions	D1122A	Protein sequencing assay	.
PAIR0040463	Mutation	V1196A	.	.
PAIR0040464	Substitutions	C481S	Protein sequencing assay	.
PAIR0040465	Mutation	V1196A	.	.
PAIR0040466	Mutation	V1196A	.	.
PAIR0040467	Mutation	V1196A	.	.
PAIR0040468	Mutation	V1196A	.	.
PAIR0040469	Mutation	V1196A	.	.
PAIR0040470	Substitutions	L2003V	Protein sequencing assay	.
PAIR0040471	Expressiom	Down-regulation	Flow cytometry	.
PAIR0040472	Missense mutation	Loss	Western blot assay; RNA extraction assay; RT-PCR; RNA sequencing assay; ChIP-qPCR; Immunohistochemistry	.
PAIR0040473	Expression	Down-regulation	Immunoprecipitation assay; LC-MS/MS analysis	EGF-EGFR signaling pathway
PAIR0040474	Expression	Up-regulation	Western blot assay; RNA extraction assay; RT-PCR; RNA sequencing assay; ChIP-qPCR; Immunohistochemistry	WNT/KDM5B/p15 signaling pathway
PAIR0040475	Mutation	V617F+L902Q	Sanger sequencing assay	.
PAIR0040476	Mutation	V617F+L902Q+R938E	Sanger sequencing assay	.
PAIR0040477	Mutation	V617F+L902Q+R947Q	Sanger sequencing assay	.
PAIR0040478	Mutation	V617F+L983F	Sanger sequencing assay	.
PAIR0040479	Mutation	V617F+L983F+Q959H	Sanger sequencing assay	.
PAIR0040480	Mutation	V617F+Y931C	Sanger sequencing assay	.
PAIR0040481	Phosphorylation	Up-regulation	Western blot assay	.
PAIR0040482	Phosphorylation	Up-regulation	Western blot assay	.
PAIR0040483	Expression	Down-regulation	Immunoblotting assay	.
PAIR0040484	Expression	Down-regulation	Ellman assay	.
PAIR0040485	Expression	Down-regulation	ELISA assay	Nrf2 signaling pathway (-|hsa05208)
PAIR0040486	Missense mutation	p.V2424G	Genotyping assay; RT-PCR	.
PAIR0040487	Expression	Down-regulation	Ellman assay	.
PAIR0040488	Expression	Down-regulation	ELISA assay	Nrf2 signaling pathway (-|hsa05208)
PAIR0040489	Expression	Down-regulation	Ellman assay	.
PAIR0040490	Expression	Down-regulation	ELISA assay	Nrf2 signaling pathway (-|hsa05208)
PAIR0040491	Phosphorylation	Down-regulation	Gene expression assay; MS analysis; Electrophoretic mobility shift assay; Phospho-GR Western blot assay	.
PAIR0040492	Phosphorylation	Down-regulation	Gene expression assay; MS analysis; Electrophoretic mobility shift assay; Phospho-GR Western blot assay	.
PAIR0040493	Expression	Up-regulation	Gene expression assay; MS analysis; Electrophoretic mobility shift assay; Phospho-GR Western blot assay	.
PAIR0040494	Expression	Down-regulation	Immunohistochemistry; Immunofluorescence staining assay; RT-PCR; Western blot assay	AKT/mTOR signaling pathway (+|hsa04150)
PAIR0040495	Expression	Down-regulation	Ellman assay	.
PAIR0040496	Expression	Down-regulation	ELISA assay	Nrf2 signaling pathway (-|hsa05208)
PAIR0040497	Expression	Up-regulation	.	.
PAIR0040498	Expression	Up-regulation	.	.
PAIR0040499	Expression	Up-regulation	Gene expression analysis	.
PAIR0040500	Expression	Down-regulation	Immunoblotting assay	.
PAIR0040501	Expression	Up-regulation	Western blot assay	MAPK signaling pathway (-|hsa04010); TORC1 signaling pathway
PAIR0040502	Mutation	R173C	GeneSeq assay; Bioinformatics assay	.
PAIR0040503	Expressiom	Down-regulation	.	.
PAIR0040504	Mutation	Q859H/K	GeneSeq assay; Bioinformatics assay	.
PAIR0040505	Mutation	rpoB gene	GeneSeq assay; Bioinformatics assay	.
PAIR0040506	Missense mutation	Q24K+L28M+R30E+A92K 	PCR; Catalase foam assay; Catalase gel assay	.
PAIR0040507	Phosphorylation	Up-regulation	MS analysis	Oxytocin signaling pathway(+|hsa04921)
PAIR0040508	Expression	Down-regulation	Western blot assay; RT-qPCR	HGF/MET signaling pathway
PAIR0040509	Expression	Down-regulation	Western blot assay	PI3K signaling pathway; Akt signaling pathway
PAIR0040510	Expression	Up-regulation	Western blot assay	PI3K signaling pathway; Akt signaling pathway
PAIR0040511	Expression	Down-regulation	Western blot assay	PI3K signaling pathway; Akt signaling pathway
PAIR0040512	Expression	Down-regulation	Western blot assay	PI3K signaling pathway; Akt signaling pathway
PAIR0040513	Expression	Down-regulation	Ellman assay	.
PAIR0040514	Expression	Down-regulation	ELISA assay	Nrf2 signaling pathway (+|hsa05208)
PAIR0040515	Methylation	Down-regulation	PCR; Docking assay	.
PAIR0040516	.	.	Gene expression analysis	.
PAIR0040517	Expression	Up-regulation	Western blot assay; Immunohistochemistry	JAK-STAT signaling pathway (+|hsa04630); AKT/mTOR signaling pathway; MAPK signaling pathway (+|hsa04010)
PAIR0040518	Mutation	rpsL gene at the 88th amino acid	GeneSeq assay; Bioinformatics assay	.
PAIR0040519	Expression	Down-regulation	Immunohistochemistry; Western blot assay; Molecular docking assay	.
PAIR0040520	Expression	Rv3795;  p.Glu378Ala	.	.
PAIR0040521	Expression	Down-regulation	Immunoblotting assay	TLR7 signaling pathway; MAPK signaling pathway (+|hsa04010); PI3K signaling pathway; JAK signaling pathway; PI3K/Akt signaling pathway (+|hsa04151); JAK/STAT3 signaling pathway (+|hsa04630)
PAIR0040522	Expression	Down-regulation	Immunoblotting assay	TLR7 signaling pathway; MAPK signaling pathway (+|hsa04010); PI3K signaling pathway; JAK signaling pathway; PI3K/Akt signaling pathway (+|hsa04151); JAK/STAT3 signaling pathway (+|hsa04630)
PAIR0040523	Mutations	92-bp deletion; A439235G	GeneSeq assay; qPCR	.
PAIR0040524	Expression	.	.	.
PAIR0040525	Mutation	H1047R	.	.
PAIR0040526	Mutation	H171R	.	.
PAIR0040527	Mutation	H171Y	.	.
PAIR0040528	Mutation	H3K27Me3	.	.
PAIR0040529	Expression	Down-regulation	Flow cytometry; Immunoblotting assay; Cytokine/Chemokine analysis; RT-qPCR; Chromatin immunoprecipitation assay	.
PAIR0040530	Expression	Down-regulation	Flow cytometry; Immunoblotting assay; Cytokine/Chemokine analysis; RT-qPCR; Chromatin immunoprecipitation assay	PI3K/AKT signaling pathway (+|hsa04151)
PAIR0040531	Phosphorylation	Up-regulation	Flow cytometry; Immunoblotting assay; Cytokine/Chemokine analysis; RT-qPCR; Chromatin immunoprecipitation assay	PI3K/AKT signaling pathway (+|hsa04151)
PAIR0040532	Expression	Up-regulation	Flow cytometry; Immunoblotting assay; Cytokine/Chemokine analysis; RT-qPCR; Chromatin immunoprecipitation assay	PI3K/AKT signaling pathway (+|hsa04151)
PAIR0040533	Methylation	Down-regulation	PCR; Docking assay	.
PAIR0040534	Expression	Up-regulation	qRT-PCR	.
PAIR0040535	Missense mutation	A1518/1519	PCR; Southern blot assay	.
PAIR0040536	Expression	.	qPCR; IHC assay	.
PAIR0040537	Expression	Down-regulation	Protein kinase assay; RT-qPCR	.
PAIR0040538	Missense mutation	G214A; G215T	GeneSeq assay; PCR	.
PAIR0040539	Mutation	Q79K	GeneSeq assay; Bioinformatics assay	.
PAIR0040540	Phosphorylation	Up-regulation	MS analysis	Oxytocin signaling pathway(+|hsa04921)
PAIR0040541	Phosphorylation	Up-regulation	MS analysis	Oxytocin signaling pathway(+|hsa04921)
PAIR0040542	Phosphorylation	Up-regulation	MS analysis	Oxytocin signaling pathway(+|hsa04921)
PAIR0040543	Phosphorylation	Up-regulation	MS analysis	Oxytocin signaling pathway(+|hsa04921)
PAIR0040544	Expression	Up-regulation	Gene expression analysis	Oxytocin signaling pathway(+|hsa04921)
PAIR0040545	Phosphorylation	Up-regulation	MS analysis	Oxytocin signaling pathway(+|hsa04921)
PAIR0040546	Phosphorylation	Up-regulation	MS analysis	Oxytocin signaling pathway(+|hsa04921)
PAIR0040547	Mutations	.	Whole exome sequencing assay; Sanger sequencing assay	.
PAIR0040548	Expression	Down-regulation	Western blot assay	Notch signaling pathway (+|hsa04330); JAK-STAT signaling pathway (+|hsa04630)
PAIR0040549	Expression	Down-regulation	Western blot assay	Notch signaling pathway (+|hsa04330); JAK-STAT signaling pathway (+|hsa04630)
PAIR0040550	Expression	Up-regulation	Western blot assay	Ca2+/calcineurin/MEK/ERK1/2 signaling pathway
PAIR0040551	Phosphorylation	Up-regulation	Western blot assay	EGFR signaling pathway (-|hsa01521)
PAIR0040552	Phosphorylation	Up-regulation	Western blot assay	EGFR signaling pathway (-|hsa01521)
PAIR0040553	Phosphorylation	Up-regulation	Western blot assay	EGFR signaling pathway (-|hsa01521)
PAIR0040554	Phosphorylation	Up-regulation	Western blot assay	EGFR signaling pathway (-|hsa01521)
PAIR0040555	Phosphorylation	Up-regulation	Western blot assay	EGFR signaling pathway (-|hsa01521)
PAIR0040556	Phosphorylation	Up-regulation	Western blot assay	EGFR signaling pathway (-|hsa01521)
PAIR0040557	Expression	Down-regulation	Western blot assay; Immunofluorescence staining assay; Immunohistochemistry; RNA sequencing assay	PI3K-Akt signaling pathway (-|hsa04151)
PAIR0040558	Function	Up-regulation	Western blot assay; Immunofluorescence staining assay; Immunohistochemistry; RNA sequencing assay	PI3K-Akt signaling pathway (-|hsa04151)
PAIR0040559	Mutation	V617F+L902Q+E1028K	Sanger sequencing assay	.
PAIR0040560	Mutation	V617F+L902Q+R938E	Sanger sequencing assay	.
PAIR0040561	Mutation	V617F+L902Q+R947Q	Sanger sequencing assay	.
PAIR0040562	Mutation	V617F+Y931C	Sanger sequencing assay	.
PAIR0040563	Mutation	V617F+L902Q+E1028K	Sanger sequencing assay	.
PAIR0040564	Expression	Up-regulation	qPCR; Western blot assay; H&E assay; Immunohistochemistry; Immunofluorescence staining assay; RNA FISH assay; RNA sequencing assay	Arachidonic acid metabolic signaling pathway
PAIR0040565	Expression	Up-regulation	qPCR; Western blot assay; Immunofluorescence staining assay; Chromatin immunoprecipitation assay	.
PAIR0040566	Expression	Up-regulation	qPCR; Western blot assay; Immunofluorescence staining assay; Chromatin immunoprecipitation assay	.
PAIR0040567	Missense mutation	F589L; G595R; G667C; F589L-G595R	Western blot assay; RT-PCR	.
PAIR0040568	Missense mutation	F589L; G595R; F589L-G595R	Western blot assay; RT-PCR	.
PAIR0040569	Expressiom	Up-regulation	.	TFAP2C-DDR1 signaling pathway
PAIR0040570	Mutantion	p.Y537N	.	.
PAIR0040571	Expressiom	Up-regulation	.	TFAP2C-DDR1 signaling pathway
PAIR0040572	Expressiom	Up-regulation	.	TFAP2C-DDR2 signaling pathway
PAIR0040573	Expressiom	Up-regulation	.	TFAP2C-DDR0 signaling pathway
PAIR0040574	Mutations	D1194A	GeneSeq assay	.
PAIR0040575	Expressiom	Up-regulation	.	TFAP2C-DDR1 signaling pathway
PAIR0040576	Expression	Up-regulation	Western blot assay	Cell autophagy (-|hsa04140)
PAIR0040577	Expression	Up-regulation	Western blot assay	Cell autophagy (-|hsa04140)
PAIR0040578	Expression	Up-regulation	Western blot assay	Cell autophagy (-|hsa04140)
PAIR0040579	Expression	Up-regulation	Western blot assay	Cell autophagy (-|hsa04140)
PAIR0040580	Expression	Up-regulation	Western blot assay; qRT-PCR	Cell autophagy (-|hsa04140)
PAIR0040581	Expression	Up-regulation	Western blot assay; qRT-PCR	Cell autophagy (-|hsa04140)
PAIR0040582	Function	Activation	Pathway enrichment analysis	TNF signaling pathway (+|hsa04668); Toll-like receptor signaling pathway (+|hsa04620); NF-kB signaling pathway (+|hsa04218); RANK-L/RANK signaling pathway
PAIR0040583	Expression	Up-regulation	Western blot assay; qRT-PCR	.
PAIR0040584	Expression	Down-regulation	.	.
PAIR0040585	Expression	Down-regulation	Western blot assay; RNA Sequencing assay; Flow cytometry	Apoptosis signaling pathway (-|hsa04210)
PAIR0040586	Missense mutation	Up-regulation	Western blot assay; RNA Sequencing assay; Flow cytometry	.
PAIR0040587	Expression	Up-regulation	Western blot assay; RNA Sequencing assay; Flow cytometry	Oxidative phosphorylation (+|hsa00190); Citrate cycle (TCA cycle) (+|hsa00020); Glutathione metabolism (+|hsa00480); Carbon metabolism (+|hsa01200)
PAIR0040588	Expression	F104L/V	Western blot assay; RNA Sequencing assay; Flow cytometry	Apoptosis signaling pathway (-|hsa04210)
PAIR0040589	Expression	Up-regulation	Western blot assay; RNA Sequencing assay; Flow cytometry	Apoptosis signaling pathway (-|hsa04210)
PAIR0040590	Expressiom	Up-regulation	Flow cytometry	.
PAIR0040591	Expression	Express CDK4	Protein component assay; Immunoblotting assay; Immunofluorescence staining assay	.
PAIR0040592	Mutation	A2064C	.	.
PAIR0040593	Mutation	K344R	.	.
PAIR0040594	Mutation	L2003M	.	.
PAIR0040595	Mutation	V106M	.	.
PAIR0040596	Mutation	Y188L	.	.
PAIR0040597	Mutation	F227L	.	.
PAIR0040598	Expression	Up-regulation	Western blot assay; RT-PCR; RNA sequencing assay; Phospho-receptor tyrosine kinase antibody arrays assay; Chromatin immunoprecipitation assay;  Luciferase reporter assay	YAP-HER3 signaling pathway
PAIR0040599	Expression	Up-regulation	qRT-PCR	.
PAIR0040600	Phosphorylation	Up-regulation	Western blot assay	PI3K/AKT/mTOR signaling pathway (-|hsa04151)
PAIR0040601	Expression	Up-regulation	Western blot assay	.
PAIR0040602	Phosphorylation	Up-regulation	Western blot assay	PI3K/AKT/mTOR signaling pathway (-|hsa04151)
PAIR0040603	Expression	Down-regulation	Western blot assay	.
PAIR0040604	Function	Activation	Cell protein extraction assay; Western blot assay; qRT-PCR; Luciferase reporter assay	PI3K/AKT signaling pathway (-|hsa04151)
PAIR0040605	Expression	Up-regulation	RT-qPCR; Western blot assay	DNA Damage Response Mechanism (DDR) comprises numerous signaling pathway
PAIR0040606	Expression	Up-regulation	RT-qPCR; Western blot assay	DNA Damage Response Mechanism (DDR) comprises numerous signaling pathway
PAIR0040607	Expression	Up-regulation	RT-qPCR; Western blot assay	DNA Damage Response Mechanism (DDR) comprises numerous signaling pathway
PAIR0040608	Expression	Up-regulation	Western blot assay	p-glycoprotein (p-gp) signaling pathway
PAIR0040609	Expression	Up-regulation	Western blot assay	p-glycoprotein (p-gp) signaling pathway
PAIR0040610	Phosphorylation	Down-regulation	High-throughput screening assay; In vitro ssSTK autophosphorylation assay	.
PAIR0040611	Methylation	Down-regulation	Western blot assay	.
PAIR0040612	Methylation	Up-regulation	Western blot assay	.
PAIR0040613	Expression	Up-regulation	Western blot assay	.
PAIR0040614	Expression	Up-regulation	Western blot assay	.
PAIR0040615	Expression	Up-regulation	.	.
PAIR0040616	Expression	Up-regulation	.	.
PAIR0040617	Expression	Down-regulation	.	.
PAIR0040618	Expression	Up-regulation	.	.
PAIR0040619	Expression	Up-regulation	PCR; RNA and miRNA extraction assay; RT-qPCR; Gene expression analysis; Immunoblotting assay; Dual-luciferase assay; Immunohistochemistry	.
PAIR0040620	Phosphorylation	Down-regulation	High-throughput screening assay; In vitro ssSTK autophosphorylation assay	.
PAIR0040621	Expression	Up-regulation	Gene expression analysis	.
PAIR0040622	Mutation	V617F+L902Q	Sanger sequencing assay	.
PAIR0040623	Mutation	V617F+L902Q+E1028K	Sanger sequencing assay	.
PAIR0040624	Mutation	V617F+L902Q+R938E	Sanger sequencing assay	.
PAIR0040625	Mutation	V617F+L902Q+R947Q	Sanger sequencing assay	.
PAIR0040626	Mutation	V617F+L983F	Sanger sequencing assay	.
PAIR0040627	Mutation	V617F+L983F+Q959H	Sanger sequencing assay	.
PAIR0040628	Mutation	V617F+Y931C	Sanger sequencing assay	.
PAIR0040629	Expression	Up-regulation	Immunofluorescence staining assay; Western blot assay	.
PAIR0040630	Expression	Up-regulation	.	.
PAIR0040631	Expressiom	Up-regulation	Flow cytometry	.
PAIR0040632	Expression	Up-regulation	Gene expression analysis	.
PAIR0040633	Phosphorylation	Up-regulation	Western blot assay	PI3K-Akt signaling pathway (+|hsa04151)
PAIR0040634	Expression	Down-regulation	Western blot assay; qRT-PCR	.
PAIR0040635	Expression	Down-regulation	Immunoblotting assay	.
PAIR0040636	Expression	Up-regulation	Western blot assay	RAS/RAF/ERK signaling pathway (+|hsa04010)
PAIR0040637	Expression	Up-regulation	High-throughput proteomics assay	RAS/RAF/ERK signaling pathway (+|hsa04010)
PAIR0040638	Expression	Up-regulation	RT-PCR	NF-kB signaling pathway (+|hsa04218)
PAIR0040639	Expression	Up-regulation	Western blot assay	NF-kB signaling pathway (+|hsa04218)
PAIR0040640	Mutations	.	Whole exome sequencing assay; Sanger sequencing assay	.
PAIR0040641	Expression	Up-regulation	Western blot assay	.
PAIR0040642	Expression	Up-regulation	.	.
PAIR0040643	Expression	S2702T	.	.
PAIR0040644	Function	Activation	Cell protein extraction assay; Western blot assay; qRT-PCR; Luciferase reporter assay	PI3K/AKT signaling pathway (-|hsa04151)
PAIR0040645	Expression	Down-regulation	Western blot assay; qRT-PCR	PI3K/AKT signaling pathway (+|hsa04151)
PAIR0040646	Expression	Up-regulation	Gene expression analysis	.
PAIR0040647	Expression	S102T	.	.
PAIR0040648	Expression	Down-regulation	Western blot assay	.
PAIR0040649	Expression	Down-regulation	Western blot assay	.
PAIR0040650	Phosphorylation	Up-regulation	Western blot assay	EGFR/STAT3/ERK signalling pathway
PAIR0040651	Phosphorylation	Up-regulation	Western blot assay	EGFR/STAT3/ERK signalling pathway
PAIR0040652	Phosphorylation	Up-regulation	Western blot assay	EGFR/STAT3/ERK signalling pathway
PAIR0040653	Expression	Down-regulation	Western blot assay	.
PAIR0040654	Expression	Up-regulation	Immunohistochemistry; Immunoblotting assay	.
PAIR0040655	Expression	Up-regulation	qRT-PCR	HGF-Met signaling pathway
PAIR0040656	Expression	Down-regulation	Western blot assay	.
PAIR0040657	Expression	Down-regulation	Western blot assay	NRF2/SLC7A11/GSH signalling pathway
PAIR0040658	Mutation	F647S	DNA sequencing assay	.
PAIR0040659	Mutation	L686F	DNA sequencing assay	.
PAIR0040660	Mutation	F647S	DNA sequencing assay	.
PAIR0040661	Mutation	"L393S, L393F, F397L, and F397I"	DNA sequencing assay	.
PAIR0040662	Mutation	L715F	DNA sequencing assay	.
PAIR0040663	Expression	H3K27Me3	Western blot assay	FGFR4 signalling pathway
PAIR0040664	Expression	Up-regulation	Proteome-ubiquitinome sequencing assay	TRIM21-USP5-MDH2 signaling pathway
PAIR0040665	Expression	Up-regulation	Western blot assay	Cell autophagy (-|hsa04140)
PAIR0040666	Mutation	.	.	MAPK-RSKs-YB-1 signaling pathway
PAIR0040667	Expression	Activation	Western blot assay; RT-PCR	ERK signaling pathway (+|hsa04210); AKT signaling pathway
PAIR0040668	Mutations	Arg622Ile	qRT-PCR; Immune cells infiltrating assay	.
PAIR0040669	Expression	Down-regulation	Western blot assay	HIF-1alpha/VEGFA/VEGFR signalling pathway
PAIR0040670	Expression	Down-regulation	Western blot assay	HIF-1alpha/VEGFA/VEGFR signalling pathway
PAIR0040671	Expression	Down-regulation	Western blot assay	HIF-1alpha/VEGFA/VEGFR signalling pathway
PAIR0040672	Expression	Up-regulation	Western blot assay	HIF-1alpha/VEGFA/VEGFR signalling pathway
PAIR0040673	Expression	Up-regulation	Western blot assay	HIF-1alpha/VEGFA/VEGFR signalling pathway
PAIR0040674	Mutations	.	Whole exome sequencing assay; Sanger sequencing assay	.
PAIR0040675	Expression	Down-regulation	qRT-PCR	.
PAIR0040676	Expression	Down-regulation	qRT-PCR	.
PAIR0040677	Phosphorylation	Up-regulation	Western blot assay	PI3K-Akt signaling pathway (+|hsa04151)
PAIR0040678	Expression	Down-regulation	.	.
PAIR0040679	Phosphorylation	Up-regulation	Western blot assay	.
PAIR0040680	Expression	Down-regulation	Flow cytometry; Transcriptome assay; qPCR	.
PAIR0040681	Phosphorylation	Up-regulation	Western blot assay	.
PAIR0040682	Expression	Down-regulation	Flow cytometry; Transcriptome assay; qPCR	.
PAIR0040683	Expression	Down-regulation	Western blot assay; qRT-PCR	.
PAIR0040684	Expression	Up-regulation	Western blot assay; qRT-PCR	.
PAIR0040685	Expression	Down-regulation	Western blot assay; qRT-PCR	.
PAIR0040686	Phosphorylation	Up-regulation	Western blot assay	PI3K/AKT signaling pathway (+|hsa04151); MAPK signaling pathway (+|hsa04010)
PAIR0040687	Phosphorylation	Up-regulation	Western blot assay	PI3K/AKT signaling pathway (+|hsa04151); MAPK signaling pathway (+|hsa04010)
PAIR0040688	Phosphorylation	Up-regulation	Western blot assay	PI3K/AKT signaling pathway (+|hsa04151); MAPK signaling pathway (+|hsa04010)
PAIR0040689	Mutation	Q24K+L28M+R30E+A92K 	TruSight oncology 500 assay	EGFR signaling pathway (-|hsa01521)
PAIR0040690	Mutation	Q24K/L28M/R30Q/A92K RASs	TruSight oncology 500 assay	EGFR signaling pathway (-|hsa01521)
PAIR0040691	Expression	Down-regulation	Western blot assay; qRT-PCR	beta2AR-Akt feedback loop signalling pathway
PAIR0040692	Expression	Down-regulation	Western blot assay; qRT-PCR	beta2AR-Akt feedback loop signalling pathway
PAIR0040693	Expression	Down-regulation	Western blot assay; qRT-PCR	beta2AR-Akt feedback loop signalling pathway
PAIR0040694	Phosphorylation	Down-regulation	Immunoblotting assay; Ubiquitination assay; Akt kinase activity assay; Immunohistochemistry	Akt-Wee1-CDK1 signaling pathway
PAIR0040695	Expression	.	Metabolomics analysis; GST pull-down assay; Coimmunoprecipitation assay	Raf-MEK-ERK-PGC1alpha signaling pathway
PAIR0040696	.	.	P-gp ATPase assay	.
PAIR0040697	.	.	P-gp ATPase assay	.
PAIR0040698	.	.	.	Wnt/beta-catenin Signalling Pathway
PAIR0040699	Expression	Down-regulation	Western blot assay	Ferroptosis signaling pathway (+|hsa04216)
PAIR0040700	Expression	Down-regulation	.	.
PAIR0040701	Expression	Down-regulation	Western blot assay	EREG/ErbB/ERK signalling pathway
PAIR0040702	Expression	Down-regulation	Western blot assay	EREG/ErbB/ERK signalling pathway
PAIR0040703	Expression	Down-regulation	Western blot assay; RT-qPCR	MAPK/ERK signaling pathway (-|hsa04011)
PAIR0040704	Mutation	.	.	.
PAIR0040705	Expression	Up-regulation	qRT-PCR	PLK1 regulatory signalling pathway; Cell cycle (+|hsa04110)
PAIR0040706	Expression	Up-regulation	Western blot assay	p-glycoprotein (p-gp) signaling pathway
PAIR0040707	Expression	Up-regulation	Western blot assay	p-glycoprotein (p-gp) signaling pathway
PAIR0040708	Missense mutation	Missense mutation	Immunoprecipitation assay; Biotin AP assay; Immunoblotting assay	Notch signaling pathway (+|hsa04330)
PAIR0040709	Missense mutation	Missense mutation	Immunoprecipitation assay; Biotin AP assay; Immunoblotting assay	Notch signaling pathway (+|hsa04330)
PAIR0040710	Expression	Amplification	qPCR; ELISA assay; Flow cytometry	TNF-alpha signaling pathway
PAIR0040711	Missense mutation	A1518/1519	PCR; Southern blot assay	.
PAIR0040712	Expression	Down-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040713	Expression	Up-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040714	Expression	Up-regulation	Fluorescent reporter assay; GC-MS	.
PAIR0040715	Methylation	Down-regulation	PCR; Docking assay	.
PAIR0040716	Expressiom	Down-regulation	Flow cytometry	.
PAIR0040717	Phosphorylation	Down-regulation	Immunoblotting assay	B cell receptor signaling pathway (-|hsa04662)
PAIR0040718	Expression	Up-regulation	.	.
PAIR0040719	Methylation	Down-regulation	Western blot assay	.
PAIR0040720	Methylation	Up-regulation	Western blot assay	.
PAIR0040721	Expression	Down-regulation	Western blot assay	.
PAIR0040722	Expression	Down-regulation	Western blot assay	.
PAIR0040723	Mutation	Missense mutation	.	.
PAIR0040724	Mutation	ORF55 K350N	.	.
PAIR0040725	Expression	Down-regulation	Flow cytometry; CCK-8 assay; qRT-PCR; Western blot assay	TLR4/NF-kappaB/HIF-1alpha signaling pathway
PAIR0040726	Expression	Up-regulation	BSP assay; NGS assay; AmpliSeq assay; Biochemical assay; Western blot assay	miRNA-34a/Notch signaling pathway
PAIR0040727	Expression	Down-regulation	qRT-PCR	.
PAIR0040728	Expression	Up-regulation	Immunohistochemistry; Immunofluorescence staining assay; RT-PCR; Western blot assay	AKT/mTOR signaling pathway (-|hsa04150)
PAIR0040729	Expression	Down-regulation	Western blot assay; qRT-PCR	Downstream AR signaling pathway
PAIR0040730	Expression	Up-regulation	Western blot assay; qRT-PCR	Downstream AR signaling pathway
PAIR0040731	Expression	Up-regulation	Western blot assay; Flow cytometry; Cytoplasmic mitochondrial DNA assay; RT-qPCR; Immunofluorescence staining assay	.
PAIR0040732	Phosphorylation	Down-regulation	Western blot assay; Flow cytometry; Cytoplasmic mitochondrial DNA assay; RT-qPCR; Immunofluorescence staining assay	.
PAIR0040733	Expression	Up-regulation	Gene expression analysis	.
PAIR0040734	Expression	Down-regulation	Western blot assay	.
PAIR0040735	Expression	Down-regulation	Gene expression analysis	.
PAIR0040736	Expression	Up-regulation	Western blot assay	ERK1/2 signaling pathway
PAIR0040737	Phosphorylation	Down-regulation	Immunoblotting assay	B cell receptor signaling pathway (-|hsa04662)
PAIR0040738	Expression	Down-regulation	Western blot assay	.
PAIR0040739	Expression	Down-regulation	Western blot assay	.
PAIR0040740	Expression	Up-regulation	.	.
PAIR0040741	Expression	Up-regulation	.	.
PAIR0040742	Expression	Down-regulation	.	.
PAIR0040743	Expression	Up-regulation	RT-PCR	NF-kB signaling pathway (+|hsa04218)
PAIR0040744	Expression	Up-regulation	Western blot assay	NF-kB signaling pathway (+|hsa04218)
PAIR0040745	Mutantion	p.Y537N	.	.
PAIR0040746	Mutantion	p.Y537N	.	.
PAIR0040747	Expression	.	qPCR	.
PAIR0040748	Expression	.	qPCR	.
PAIR0040749	Missense mutation	A1518/1519	PCR; Southern blot assay	.
PAIR0040750	Mutation	I84V	.	.
PAIR0040751	Expression	Down-regulation	qRT-PCR; Western blot assay; Flow cytometry	.
PAIR0040752	Mutation	V1196A	.	.
PAIR0040753	Mutation	V1196A	.	.
PAIR0040754	Mutation	V1196A	.	.
PAIR0040755	Substitutions	Rv0667; ?p.Asp435Phe	Protein sequencing assay	.
PAIR0040756	Phosphorylation	Down-regulation	High-throughput screening assay; In vitro ssSTK autophosphorylation assay	.
PAIR0040757	Expression	Up-regulation	Western blot assay	p-glycoprotein (p-gp) signaling pathway
PAIR0040758	Expression	Up-regulation	Western blot assay	p-glycoprotein (p-gp) signaling pathway
PAIR0040759	Phosphorylation	Up-regulation	Western blot assay	EGFR/STAT3 signaling pathway (-|hsa01521)
PAIR0040760	Phosphorylation	Up-regulation	Western blot assay	EGFR/STAT3 signaling pathway (-|hsa01521)
PAIR0040761	Phosphorylation	Up-regulation	Western blot assay	EGFR/STAT3 signaling pathway (-|hsa01521)
PAIR0040762	Phosphorylation	Up-regulation	Western blot assay	EGFR/STAT3 signaling pathway (-|hsa01521)
PAIR0040763	Expression	Up-regulation	Western blot assay	ERK1/2 signaling pathway
PAIR0040764	Expression	Up-regulation	Immunofluorescence staining assay; Western blot assay	.
PAIR0040765	Expression	Up-regulation	.	.
PAIR0040766	Mutation	I830V	.	.
PAIR0040767	Expression	D1194A+R1181K+A1182V+Q1106K/R+T1080S	.	.
PAIR0040768	Missense mutation	p.Y537N	GeneSeq assay; Molecular docking assay	.
PAIR0040769	Expression	Up-regulation	Western blot assay; qRT-PCR	MAPK-RSKs-YB-1 signaling pathway
PAIR0040770	Missense mutation	"EGFR-K745_E746insIPVAIK; Exon 19 deletion, L858R, L861Q, G719S, A763_Y764insFQEA"	GeneSeq assay	PI3K-Akt signaling pathway (-|hsa04151)
PAIR0040771	Missense mutation	"EGFR-K745_E746insIPVAIK; Exon 19 deletion, L858R, L861Q, G719S, A763_Y764insFQEA"	GeneSeq assay	PI3K-Akt signaling pathway (-|hsa04151)
PAIR0040772	Mutantion	p.Y537N	.	.
PAIR0040773	Missense mutation	G595R; F589L-G595R	Western blot assay; RT-PCR	.
PAIR0040774	Mutantion	p.Y537N	.	.
PAIR0040775	Expression	Down-regulation	Immunoblotting assay	TNF signaling pathway (+|hsa04668); IL-18 signaling pathway; interferon gamma signaling pathway; B cell receptor signaling pathway (+|hsa04662); PI3K signaling pathway
PAIR0040776	Phosphorylation	Down-regulation	Immunoblotting assay	TNF signaling pathway (+|hsa04668); IL-18 signaling pathway; interferon gamma signaling pathway; B cell receptor signaling pathway (+|hsa04662); PI3K signaling pathway
PAIR0040777	Expression	C2617A; A2063G	Immunoblotting assay	TNF signaling pathway (+|hsa04668); IL-18 signaling pathway; interferon gamma signaling pathway; B cell receptor signaling pathway (+|hsa04662); PI3K signaling pathway
PAIR0040778	Phosphorylation	Down-regulation	High-throughput screening assay; In vitro ssSTK autophosphorylation assay	.
PAIR0040779	Missense mutation	G464S	Western blot assay; RT-PCR	.
PAIR0040780	Phosphorylation	H3K27Me3	Western blot assay	MEK/ERK signaling pathway (+|hsa04010); JAK2/STAT3 signaling pathway; PI3K-Akt signaling pathway (+|hsa04151)
PAIR0040781	Phosphorylation	H3K27Me3	Western blot assay	MEK/ERK signaling pathway (+|hsa04010); JAK2/STAT3 signaling pathway; PI3K-Akt signaling pathway (+|hsa04151)
PAIR0040782	Phosphorylation	H3K27Me3	Western blot assay	MEK/ERK signaling pathway (+|hsa04010); JAK2/STAT3 signaling pathway; PI3K-Akt signaling pathway (+|hsa04151)
PAIR0040783	Expression	Down-regulation	Western blot assay; Immunohistochemistry; Immunofluorescence staining assay	MAPK signaling pathway (+|hsa04010); AKT/mTOR signaling pathway (+|hsa04150)
PAIR0040784	Mutantion	p.Y537N	.	.
PAIR0040785	Mutantion	p.Y537N	.	.
PAIR0040786	Mutantion	p.Y537N	.	.
PAIR0040787	Phosphorylation	H3K27Me3	Western blot assay	MEK/ERK signaling pathway(+|hsa04010); JAK2/STAT3 signaling pathway (+|hsa04151)
PAIR0040788	Phosphorylation	H3K27Me3	Western blot assay	MEK/ERK signaling pathway(+|hsa04010); JAK2/STAT3 signaling pathway (+|hsa04151)
PAIR0040789	Phosphorylation	I50V	Western blot assay	MEK/ERK signaling pathway(+|hsa04010); JAK2/STAT3 signaling pathway (+|hsa04151)
PAIR0040790	Phosphorylation	I827V	Western blot assay	MEK/ERK signaling pathway(+|hsa04010); JAK2/STAT3 signaling pathway (+|hsa04151)
PAIR0040791	Missense mutation	Rv1630; ?p.Ala440Thr	Kinase inhibition assay; Transfection assay; Western blot assay; Proximity ligation assay	.
PAIR0040792	Missense mutation	L715F	Kinase inhibition assay; Transfection assay; Western blot assay; Proximity ligation assay	.
PAIR0040793	Mutation	Missense mutation	.	.
PAIR0040794	Mutation	.	.	.
PAIR0040795	Expression	Down-regulation	RT-qPCR; Western blot assay	PI3K/AKT signaling pathway (-|hsa04151)
PAIR0040796	Expression	Down-regulation	Flow cytometry	.
PAIR0040797	Function	Activation	Flow cytometry	.
PAIR0040798	Loss	Up-regulation	Flow cytometry	.
PAIR0040799	Expression	Down-regulation	Western blot assay; RNA extraction assay; qRT-PCR; ERalpha degradation high-content imaging assay; Ki67 assay; beta-galactosidase assay; TUNEL assay	.
PAIR0040800	Expressiom	Up-regulation	Flow cytometry	.
PAIR0040801	.	.	.	MEK signaling pathway (+|hsa04011)
PAIR0040802	Phosphorylation	Up-regulation	Western blot assay	.
PAIR0040803	Expression	Up-regulation	.	.
PAIR0040804	Mutation	V600E	TruSight oncology 500 assay	EGFR signaling pathway (-|hsa01521)
PAIR0040805	Mutation	V600E	TruSight oncology 500 assay	EGFR signaling pathway (-|hsa01521)
PAIR0040806	Expression	Down-regulation	Flow cytometry; Transcriptome assay; qPCR	.
PAIR0040807	Expression	Up-regulation	Western blot assay; qRT-PCR	p38 MAPK signaling pathway
PAIR0040808	Expression	Down-regulation	Western blot assay	Notch signaling pathway (+|hsa04330); JAK-STAT signaling pathway (+|hsa04630)
PAIR0040809	Expression	Up-regulation	Western blot assay	Notch signaling pathway (+|hsa04330); JAK-STAT signaling pathway (+|hsa04630)
PAIR0040810	Expression	.	.	RAS/RAF/ERK signaling pathway (-|hsa04010)
PAIR0040811	Expression	Down-regulation	.	Cell autophagy (-|hsa04140)
PAIR0040812	Expression	Down-regulation	Immunofluorescence staining assay	.
PAIR0040813	Expression	Down-regulation	Immunofluorescence staining assay	.
PAIR0040814	Activity	A2067G	.	.
PAIR0040815	Phosphorylation	Up-regulation	Western blot assay; qRT-PCR	EGFR/PI3K/Akt signaling pathway
PAIR0040816	Expression	Down-regulation	qPCR; qRT-PCR	.
PAIR0040817	Expression	Up-regulation	qPCR; qRT-PCR	.
PAIR0040818	Expression	Up-regulation	qPCR; qRT-PCR	.
PAIR0040819	Expression	Up-regulation	qPCR; qRT-PCR	.
PAIR0040820	Expression	Up-regulation	qPCR; qRT-PCR	.
PAIR0040821	Expression	Up-regulation	qPCR; qRT-PCR	.
PAIR0040822	Missense mutation	Down-regulation	Protein component assay; Immunoblotting assay; Immunofluorescence staining assay	.
PAIR0040823	Expression	Down-regulation	Protein component assay; Immunoblotting assay; Immunofluorescence staining assay	PI3K/AKT signaling pathway (-|hsa04151)
PAIR0040824	Expression	Down-regulation	qRT?PCR	.
PAIR0040825	Expression	Down-regulation	qRT?PCR	.
PAIR0040826	Expression	Down-regulation	qRT?PCR	.
PAIR0040827	Expression	Up-regulation	qRT?PCR	.
PAIR0040828	Expression	Up-regulation	qRT?PCR	.
PAIR0040829	Expression	Down-regulation	qRT?PCR	.
PAIR0040830	Expression	GGH lacking N-terminal signal peptide (GGH?deltaN)	Cryopulverization assay; DNA/RNA extraction assay; Whole exome sequencing assay; RNA sequencing assay; Immunoblotting assay; Gene expression analysis	Ras/Raf/MEK/ERK signaling pathway; mTORC1/2 signaling pathway; VEGFR/c-MET/AXL signaling pathway
PAIR0040831	Missense mutation	Up-regulation	Cryopulverization assay; DNA/RNA extraction assay; Whole exome sequencing assay; RNA sequencing assay; Immunoblotting assay; Gene expression analysis	Ras/Raf/MEK/ERK signaling pathway; mTORC1/2 signaling pathway; VEGFR/c-MET/AXL signaling pathway
PAIR0040832	Expression	Activation	Western blot assay; Immunofluorescence staining assay; Immunohistochemistry; RNA sequencing assay	PI3K-Akt signaling pathway (-|hsa04151)
PAIR0040833	.	.	.	.
PAIR0040834	.	.	Gene expression analysis	.
PAIR0040835	Expression	Up-regulation	GeneSeq assay; Western blot assay	.
PAIR0040836	Expression	Down-regulation	GeneSeq assay; Western blot assay	.
PAIR0040837	Expression	Up-regulation	Western blot assay; RT-PCR	YAP-MCL-1 signaling pathway
PAIR0040838	Function	Up-regulation	Western blot assay; RT-PCR	BCL-2 family-mediated apoptotic signaling pathway
PAIR0040839	Mutations	.	Immunoblotting assay; RT-PCR; Quantitative immunohistochemistry	MET signaling pathway (+|hsa04150)
PAIR0040840	Expression	Up-regulation	Antibodies assay; Western blot assay; qRT-PCR	Mevalonate signaling pathway
PAIR0040841	Mutations	Q24K/L28M/R30Q/A92K RASs	Amino acid substitutions assay	.
PAIR0040842	Expression	Down-regulation	qRT-PCR; Western blot assay 	MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway
PAIR0040843	Expression	Down-regulation	qRT-PCR; Western blot assay 	MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway
PAIR0040844	Expression	Up-regulation	qRT-PCR; Immunoblotting assay	.
PAIR0040845	Expression	Up-regulation	qRT-PCR; Immunoblotting assay	.
PAIR0040846	Expression	Down-regulation	qRT-PCR; Immunoblotting assay	.
PAIR0040847	Expression	Down-regulation	qRT-PCR; Immunoblotting assay	.
PAIR0040848	Mutantion	p.Y537N	.	.
PAIR0040849	Mutantion	p.Y537N	.	.
PAIR0040850	Mutantion	p.Y537N	.	.
PAIR0040851	Expressiom	Up-regulation	.	TFAP2C-DDR1 signaling pathway
PAIR0040852	Expressiom	Up-regulation	.	TFAP2C-DDR1 signaling pathway
PAIR0040853	Expressiom	Up-regulation	.	.
PAIR0040854	phosphorylation	Up-regulation	Western blot assay	.
PAIR0040855	Expression	Up-regulation	.	.
PAIR0040856	Expression	Up-regulation	.	.
PAIR0040857	Mutation	.	.	.
PAIR0040858	Mutation	.	.	.
PAIR0040859	Mutation	.	.	PI3K-Akt signaling pathway (+|hsa04151)
PAIR0040860	Expression	Up-regulation	Western blot assay	Oxidative stress response signaling pathway
PAIR0040861	Expression	Up-regulation	qRT-PCR	HGF-Met signaling pathway
PAIR0040862	Phosphorylation	Down-regulation	Immunoblotting assay	B cell receptor signaling pathway (-|hsa04662)
PAIR0040863	Phosphorylation	Down-regulation	Immunoblotting assay	B cell receptor signaling pathway (-|hsa04662)
PAIR0040864	Phosphorylation	Down-regulation	Immunoblotting assay	B cell receptor signaling pathway (-|hsa04662)
PAIR0040865	Phosphorylation	Down-regulation	Immunoblotting assay	B cell receptor signaling pathway (-|hsa04662)
PAIR0040866	Phosphorylation	Down-regulation	Immunoblotting assay	B cell receptor signaling pathway (-|hsa04662)
PAIR0040867	Expression	Up-regulation	qRT-PCR; Flow cytometry; Protein analyses; Immunofluorescence staining assay; Confocal microscopy assay	PI3K-AKT signaling pathway (+|hsa04151); RAS-ERK signaling pathway; NF-kappaB signaling pathway (+|hsa04218)
PAIR0040868	Expression	Up-regulation	qRT-PCR; Flow cytometry; Protein analyses; Immunofluorescence staining assay; Confocal microscopy assay	PI3K-AKT signaling pathway (+|hsa04151); RAS-ERK signaling pathway; NF-kappaB signaling pathway (+|hsa04218)
PAIR0040869	Expression	Up-regulation	qRT-PCR; Flow cytometry; Protein analyses; Immunofluorescence staining assay; Confocal microscopy assay	PI3K-AKT signaling pathway (+|hsa04151); RAS-ERK signaling pathway; NF-kappaB signaling pathway (+|hsa04218)
PAIR0040870	Expression	Up-regulation	qRT-PCR; Flow cytometry; Protein analyses; Immunofluorescence staining assay; Confocal microscopy assay	PI3K-AKT signaling pathway (+|hsa04151); RAS-ERK signaling pathway; NF-kappaB signaling pathway (+|hsa04218)
PAIR0040871	Expression	Up-regulation	qRT-PCR; Flow cytometry; Protein analyses; Immunofluorescence staining assay; Confocal microscopy assay	PI3K-AKT signaling pathway (+|hsa04151); RAS-ERK signaling pathway; NF-kappaB signaling pathway (+|hsa04218)
PAIR0040872	Expression	Up-regulation	qRT-PCR; Flow cytometry; Protein analyses; Immunofluorescence staining assay; Confocal microscopy assay	PI3K-AKT signaling pathway (+|hsa04151); RAS-ERK signaling pathway; NF-kappaB signaling pathway (+|hsa04218)
PAIR0040873	Expression	Up-regulation	Flow cytometry; Immunohistochemistry; Cytokine assay	Th1-type immune response signaling pathway
PAIR0040874	Expression	Up-regulation	Flow cytometry; Immunohistochemistry; Cytokine assay	Th1-type immune response signaling pathway
PAIR0040875	Expression	Up-regulation	Flow cytometry; Immunohistochemistry; Cytokine assay	Th1-type immune response signaling pathway
PAIR0040876	Expression	Down-regulation	Western blot assay; Molecular docking assay	.
PAIR0040877	Expression	Down-regulation	Western blot assay; Molecular docking assay	MEK/ERK signaling pathway (-|hsa04011)
PAIR0040878	Expression	Down-regulation	Western blot assay; Molecular docking assay	MEK/ERK signaling pathway (-|hsa04011)
PAIR0040879	Expression	Down-regulation	Western blot assay; Molecular docking assay	MEK/ERK signaling pathway (-|hsa04011)
PAIR0040880	Expression	Down-regulation	Western blot assay; Molecular docking assay	.
PAIR0040881	Expression	Down-regulation	Western blot assay; Molecular docking assay	.
PAIR0040882	Expression	Down-regulation	Western blot assay; Molecular docking assay	MEK/ERK signaling pathway (-|hsa04011)
PAIR0040883	Expression	Down-regulation	Western blot assay; Molecular docking assay	MEK/ERK signaling pathway (-|hsa04011)
PAIR0040884	Expression	Down-regulation	Western blot assay; Molecular docking assay	MEK/ERK signaling pathway (-|hsa04011)
PAIR0040885	Expression	Down-regulation	Western blot assay; Molecular docking assay	.
PAIR0040886	Missense mutation	Loss	Immunoprecipitation assay; Biotin AP assay; Immunoblotting assay	Notch signaling pathway (-|hsa04330)
PAIR0040887	Missense mutation	Loss	Immunoprecipitation assay; Biotin AP assay; Immunoblotting assay	Notch signaling pathway (-|hsa04330)
PAIR0040888	Expression	Up-regulation	Western blot assay; Fluorescence in situ hybridization assay; Histology assay; Immunohistochemistry; qRT-PCR; Flow cytometry	Phosphatidylinositol 3-kinase gamma (PI3K-gamma) signaling pathway
PAIR0040889	Phosphorylation	Up-regulation	Gene expression profiling assay; Flow cytometry; Western blot assay; ELISA assay	IRAK-1 and-4 signaling pathway
PAIR0040890	Expression	Down-regulation	Gel-based protein profiling assay; MS analysis; Enzymatic activity assay; Thermal shift assay; SPR assay; RNA isolation assay; RT-PCR	.
PAIR0040891	Expression	Loss	PCR; RNA and miRNA extraction assay; RT-qPCR; Gene expression analysis; Immunoblotting assay; Dual-luciferase assay; Immunohistochemistry	.
PAIR0040892	Missense mutation	Up-regulation	PCR; RNA and miRNA extraction assay; RT-qPCR; Gene expression analysis; Immunoblotting assay; Dual-luciferase assay; Immunohistochemistry	.
PAIR0040893	Expression	Down-regulation	SEM assay; TEM assay; EtBr accumulation assay; qRT-PCR; Western blot assay; Bocillin FL PBP binding assay; beta-Lactamase activity assay	Efflux pumps of MRSA2 signaling pathway
PAIR0040894	Expression	Down-regulation	Antibodies assay; Western blot assay; qRT-PCR	Mevalonate signaling pathway
PAIR0040895	Expression	Down-regulation	Western blot assay; SDS-PAGE assay; qRT-PCR	Aerobic glycolysis-ROS-autophagy signaling pathway
PAIR0040896	Expression	Up-regulation	Western blot assay	AKT signaling pathway; NF-kB signaling pathway (+|hsa04218)
PAIR0040897	Expressiom	Down-regulation	.	.
PAIR0040898	Expression	Down-regulation	Immunohistochemistry; ELISA assay; RNA immunoprecipitation assay; RT-qPCR; Western blot assay	.
PAIR0040899	Expression	Down-regulation	Immunohistochemistry; ELISA assay; RNA immunoprecipitation assay; RT-qPCR; Western blot assay	.